| http://purl.uniprot.org/citations/12682072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12682072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12682072 | http://www.w3.org/2000/01/rdf-schema#comment | "PELP1 (proline-, glutamic acid-, and leucine-rich protein-1 (also referred to as MNAR, or modulator of nongenomic activity of estrogen receptor)), a recently identified novel coactivator of estrogen receptors, is widely expressed in a variety of 17 beta-estradiol (E2)-responsive reproductive tissues and is developmentally regulated in mammary glands. pRb (retinoblastoma protein), a cell cycle switch protein, plays a fundamental role in the proliferation, development, and differentiation of eukaryotic cells. To study the putative function of PELP1, we established stable MCF-7 breast cancer cell lines overexpressing PELP1. PELP1 overexpression hypersensitized breast cancer cells to E2 signaling, enhanced progression of breast cancer cells to S phase, and led to persistent hyperphosphorylation of pRb in an E2-dependent manner. Using phosphorylation site-specific pRb antibodies, we identified Ser-807/Ser-811 of pRb as a potential target site of PELP1. Interestingly, PELP1 was discovered to be physiologically associated with pRb and interacted via its C-terminal pocket domain, and PELP1/pRb interaction could be modulated by antiestrogen agents. Using mutant pRb cells, we demonstrated an essential role for PELP1/pRb interactions in the maximal coactivation functions of PELP1 using cyclin D1 as one of the targets. Taken together, these findings suggest that PELP1, a steroid coactivator, plays a permissive role in E2-mediated cell cycle progression, presumably via its regulatory interaction with the pRb pathway."xsd:string |
| http://purl.uniprot.org/citations/12682072 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m212822200"xsd:string |
| http://purl.uniprot.org/citations/12682072 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m212822200"xsd:string |
| http://purl.uniprot.org/citations/12682072 | http://purl.uniprot.org/core/author | "Vadlamudi R.K."xsd:string |
| http://purl.uniprot.org/citations/12682072 | http://purl.uniprot.org/core/author | "Vadlamudi R.K."xsd:string |
| http://purl.uniprot.org/citations/12682072 | http://purl.uniprot.org/core/author | "Balasenthil S."xsd:string |
| http://purl.uniprot.org/citations/12682072 | http://purl.uniprot.org/core/author | "Balasenthil S."xsd:string |
| http://purl.uniprot.org/citations/12682072 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12682072 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12682072 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12682072 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12682072 | http://purl.uniprot.org/core/pages | "22119-22127"xsd:string |
| http://purl.uniprot.org/citations/12682072 | http://purl.uniprot.org/core/pages | "22119-22127"xsd:string |
| http://purl.uniprot.org/citations/12682072 | http://purl.uniprot.org/core/title | "Functional interactions between the estrogen receptor coactivator PELP1/MNAR and retinoblastoma protein."xsd:string |
| http://purl.uniprot.org/citations/12682072 | http://purl.uniprot.org/core/title | "Functional interactions between the estrogen receptor coactivator PELP1/MNAR and retinoblastoma protein."xsd:string |
| http://purl.uniprot.org/citations/12682072 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12682072 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12682072 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12682072 |
| http://purl.uniprot.org/citations/12682072 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12682072 |
| http://purl.uniprot.org/citations/12682072 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12682072 |
| http://purl.uniprot.org/citations/12682072 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12682072 |
| http://purl.uniprot.org/uniprot/P06400 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12682072 |
| http://purl.uniprot.org/uniprot/Q8IZL8 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12682072 |