| http://purl.uniprot.org/citations/12682111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12682111 | http://www.w3.org/2000/01/rdf-schema#comment | "In addition to their CD1d-restricted T cell receptor (TCR), natural killer T (NKT) cells express various receptors normally associated with NK cells thought to act, in part, as modulators of TCR signaling. Immunoreceptor-tyrosine activation (ITAM) and inhibition (ITIM) motifs associated with NK receptors may augment or attenuate perceived TCR signals respectively, potentially influencing NKT cell development and function. ITIM-containing Ly49 family receptors expressed by NKT cells are proposed to play a role in their development and function. We have produced mice transgenic for the ITAM-associated Ly49D and ITIM-containing Ly49A receptors and their common ligand H2-Dd to determine the importance of these signaling interplays in NKT cell development. Ly49D/H2-Dd transgenic mice had selectively and severely reduced numbers of thymic and peripheral NKT cells, whereas both ligand and Ly49D transgenics had normal numbers of NKT cells. CD1d tetramer staining revealed a blockade of NKT cell development at an early precursor stage. Coexpression of a Ly49A transgene partially rescued NKT cell development in Ly49D/H2-Dd transgenics, presumably due to attenuation of ITAM signaling. Thus, Ly49D-induced ITAM signaling is incompatible with the early development of cells expressing semi-invariant CD1d-restricted TCRs and appropriately harmonized ITIM-ITAM signaling is likely to play an important role in the developmental program of NKT cells."xsd:string |
| http://purl.uniprot.org/citations/12682111 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20021615"xsd:string |
| http://purl.uniprot.org/citations/12682111 | http://purl.uniprot.org/core/author | "Zimmer J."xsd:string |
| http://purl.uniprot.org/citations/12682111 | http://purl.uniprot.org/core/author | "Schumann J."xsd:string |
| http://purl.uniprot.org/citations/12682111 | http://purl.uniprot.org/core/author | "Held W."xsd:string |
| http://purl.uniprot.org/citations/12682111 | http://purl.uniprot.org/core/author | "Beermann F."xsd:string |
| http://purl.uniprot.org/citations/12682111 | http://purl.uniprot.org/core/author | "MacDonald H.R."xsd:string |
| http://purl.uniprot.org/citations/12682111 | http://purl.uniprot.org/core/author | "Voyle R.B."xsd:string |
| http://purl.uniprot.org/citations/12682111 | http://purl.uniprot.org/core/author | "Lees R.K."xsd:string |
| http://purl.uniprot.org/citations/12682111 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12682111 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/12682111 | http://purl.uniprot.org/core/pages | "919-925"xsd:string |
| http://purl.uniprot.org/citations/12682111 | http://purl.uniprot.org/core/title | "Ligand-dependent inhibition of CD1d-restricted NKT cell development in mice transgenic for the activating receptor Ly49D."xsd:string |
| http://purl.uniprot.org/citations/12682111 | http://purl.uniprot.org/core/volume | "197"xsd:string |
| http://purl.uniprot.org/citations/12682111 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12682111 |
| http://purl.uniprot.org/citations/12682111 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12682111 |
| http://purl.uniprot.org/uniprot/#_A0A2Z4T220-mappedCitation-12682111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12682111 |
| http://purl.uniprot.org/uniprot/#_A0A2Z4T230-mappedCitation-12682111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12682111 |
| http://purl.uniprot.org/uniprot/#_A0A2Z4T2D5-mappedCitation-12682111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12682111 |
| http://purl.uniprot.org/uniprot/#_A0A2Z4T3E0-mappedCitation-12682111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12682111 |
| http://purl.uniprot.org/uniprot/#_A0A482D1Q0-mappedCitation-12682111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12682111 |
| http://purl.uniprot.org/uniprot/#_A0A2Z4SXR9-mappedCitation-12682111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12682111 |
| http://purl.uniprot.org/uniprot/#_A0A2Z4SY50-mappedCitation-12682111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12682111 |
| http://purl.uniprot.org/uniprot/#_A0A2Z4SY68-mappedCitation-12682111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12682111 |