| http://purl.uniprot.org/citations/12682224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12682224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12682224 | http://www.w3.org/2000/01/rdf-schema#comment | "The tec family kinase, inducible T cell tyrosine kinase (Itk), is critical for both development and activation of T lymphocytes. We have found that Itk regulates TCR/CD3-induced actin-dependent cytoskeletal events. Expression of Src homology (SH) 2 domain mutant Itk transgenes into Jurkat T cells inhibits these events. Furthermore, Itk(-/-) murine T cells display significant defects in TCR/CD3-induced actin polymerization. In addition, Jurkat cells deficient in linker for activation of T cells expression, an adaptor critical for Itk activation, display impaired cytoskeletal events and expression of SH3 mutant Itk transgenes reconstitutes this impairment. Interestingly, expression of an Itk kinase-dead mutant transgene into Jurkat cells has no effect on cytoskeletal events. Collectively, these data suggest that Itk regulates TCR/CD3-induced actin-dependent cytoskeletal events, possibly in a kinase-independent fashion."xsd:string |
| http://purl.uniprot.org/citations/12682224 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.170.8.3971"xsd:string |
| http://purl.uniprot.org/citations/12682224 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.170.8.3971"xsd:string |
| http://purl.uniprot.org/citations/12682224 | http://purl.uniprot.org/core/author | "Tsoukas C.D."xsd:string |
| http://purl.uniprot.org/citations/12682224 | http://purl.uniprot.org/core/author | "Tsoukas C.D."xsd:string |
| http://purl.uniprot.org/citations/12682224 | http://purl.uniprot.org/core/author | "Browne C.D."xsd:string |
| http://purl.uniprot.org/citations/12682224 | http://purl.uniprot.org/core/author | "Browne C.D."xsd:string |
| http://purl.uniprot.org/citations/12682224 | http://purl.uniprot.org/core/author | "Grasis J.A."xsd:string |
| http://purl.uniprot.org/citations/12682224 | http://purl.uniprot.org/core/author | "Grasis J.A."xsd:string |
| http://purl.uniprot.org/citations/12682224 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12682224 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12682224 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/12682224 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/12682224 | http://purl.uniprot.org/core/pages | "3971-3976"xsd:string |
| http://purl.uniprot.org/citations/12682224 | http://purl.uniprot.org/core/pages | "3971-3976"xsd:string |
| http://purl.uniprot.org/citations/12682224 | http://purl.uniprot.org/core/title | "Inducible T cell tyrosine kinase regulates actin-dependent cytoskeletal events induced by the T cell antigen receptor."xsd:string |
| http://purl.uniprot.org/citations/12682224 | http://purl.uniprot.org/core/title | "Inducible T cell tyrosine kinase regulates actin-dependent cytoskeletal events induced by the T cell antigen receptor."xsd:string |
| http://purl.uniprot.org/citations/12682224 | http://purl.uniprot.org/core/volume | "170"xsd:string |
| http://purl.uniprot.org/citations/12682224 | http://purl.uniprot.org/core/volume | "170"xsd:string |
| http://purl.uniprot.org/citations/12682224 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12682224 |
| http://purl.uniprot.org/citations/12682224 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12682224 |
| http://purl.uniprot.org/citations/12682224 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12682224 |
| http://purl.uniprot.org/citations/12682224 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12682224 |