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| Subject | Predicate | Object |
|---|---|---|
| http://purl.uniprot.org/citations/12687700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12687700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12687700 | http://www.w3.org/2000/01/rdf-schema#comment | "Synaptic vesicle protein 2 (SV2), a ubiquitous synaptic vesicle protein, is known to participate in the regulation of Ca(2+)-mediated synaptic transmission, although its precise function has not been established. Three SV2 isoforms (SV2A, SV2B, SV2C) have been identified recently, each of which has a unique distribution in brain, suggesting synapse-specific functions. To determine if SV2A, -B, and -C are differentially distributed among synapses in the retina and the sequence of their development, we examined their distribution and expression patterns immunocytochemically in adult and developing mouse retina. The three SV2 isoforms were differentially distributed in the synapses of the two plexiform layers in the adult retina. SV2A was present in cone, but not rod, terminals in the outer plexiform layer (OPL) and in many synaptic terminals in the inner plexiform layer (IPL). SV2B was present only in the ribbon synapse-containing terminals of rod and cone photoreceptors and bipolar cells. SV2C was present in starburst amacrine cells, other conventional synapses in the IPL of unknown origin, and in presumptive interplexiform cell terminals in the INL and OPL. Each SV2 isoform was expressed in its distinct presynaptic terminals early and throughout postnatal development. In addition, SV2A was transiently expressed by developing horizontal cells. The unique distribution of each isoform suggests potentially distinct functions at different types of synapses, with SV2B having ribbon synapse-specific functions, and SV2C being important for the functions of starburst amacrine cells. Rod and cone terminals contain different complements of SV2 isoforms, indicating that ribbon synapses are not all identical. The early expression of SV2 isoforms prior to initiation of synapse formation suggests that they may have important synapse-specific roles during synaptogenesis."xsd:string |
| http://purl.uniprot.org/citations/12687700 | http://purl.org/dc/terms/identifier | "doi:10.1002/cne.10636"xsd:string |
| http://purl.uniprot.org/citations/12687700 | http://purl.org/dc/terms/identifier | "doi:10.1002/cne.10636"xsd:string |
| http://purl.uniprot.org/citations/12687700 | http://purl.uniprot.org/core/author | "Janz R."xsd:string |
| http://purl.uniprot.org/citations/12687700 | http://purl.uniprot.org/core/author | "Janz R."xsd:string |
| http://purl.uniprot.org/citations/12687700 | http://purl.uniprot.org/core/author | "Wang M.M."xsd:string |
| http://purl.uniprot.org/citations/12687700 | http://purl.uniprot.org/core/author | "Wang M.M."xsd:string |
| http://purl.uniprot.org/citations/12687700 | http://purl.uniprot.org/core/author | "Belizaire R."xsd:string |
| http://purl.uniprot.org/citations/12687700 | http://purl.uniprot.org/core/author | "Belizaire R."xsd:string |
| http://purl.uniprot.org/citations/12687700 | http://purl.uniprot.org/core/author | "Sherry D.M."xsd:string |
| http://purl.uniprot.org/citations/12687700 | http://purl.uniprot.org/core/author | "Sherry D.M."xsd:string |
| http://purl.uniprot.org/citations/12687700 | http://purl.uniprot.org/core/author | "Frishman L.J."xsd:string |
| http://purl.uniprot.org/citations/12687700 | http://purl.uniprot.org/core/author | "Frishman L.J."xsd:string |
| http://purl.uniprot.org/citations/12687700 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12687700 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12687700 | http://purl.uniprot.org/core/name | "J. Comp. Neurol."xsd:string |
| http://purl.uniprot.org/citations/12687700 | http://purl.uniprot.org/core/name | "J. Comp. Neurol."xsd:string |
| http://purl.uniprot.org/citations/12687700 | http://purl.uniprot.org/core/pages | "106-122"xsd:string |
| http://purl.uniprot.org/citations/12687700 | http://purl.uniprot.org/core/pages | "106-122"xsd:string |
| http://purl.uniprot.org/citations/12687700 | http://purl.uniprot.org/core/title | "Differential distribution and developmental expression of synaptic vesicle protein 2 isoforms in the mouse retina."xsd:string |
| http://purl.uniprot.org/citations/12687700 | http://purl.uniprot.org/core/title | "Differential distribution and developmental expression of synaptic vesicle protein 2 isoforms in the mouse retina."xsd:string |
| http://purl.uniprot.org/citations/12687700 | http://purl.uniprot.org/core/volume | "460"xsd:string |
| http://purl.uniprot.org/citations/12687700 | http://purl.uniprot.org/core/volume | "460"xsd:string |