| http://purl.uniprot.org/citations/12689591 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12689591 | http://www.w3.org/2000/01/rdf-schema#comment | "Microtubules (MTs) play an important role in elaboration and maintenance of axonal and dendritic processes. MT dynamics are modulated by MT-associated proteins (MAPs), whose activities are regulated by protein phosphorylation. We found that a member of the c-Jun NH(2)-terminal protein kinase (JNK) subgroup of MAP kinases, JNK1, is involved in regulation of MT dynamics in neuronal cells. Jnk1(-/-) mice exhibit disrupted anterior commissure tract formation and a progressive loss of MTs within axons and dendrites. MAP2 and MAP1B polypeptides are hypophosphorylated in Jnk1(-/-) brains, resulting in compromised ability to bind MTs and promote their assembly. These results suggest that JNK1 is required for maintaining the cytoskeletal integrity of neuronal cells and is a critical regulator of MAP activity and MT assembly."xsd:string |
| http://purl.uniprot.org/citations/12689591 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1534-5807(03)00094-7"xsd:string |
| http://purl.uniprot.org/citations/12689591 | http://purl.uniprot.org/core/author | "Chang L."xsd:string |
| http://purl.uniprot.org/citations/12689591 | http://purl.uniprot.org/core/author | "Goldstein L.S."xsd:string |
| http://purl.uniprot.org/citations/12689591 | http://purl.uniprot.org/core/author | "Karin M."xsd:string |
| http://purl.uniprot.org/citations/12689591 | http://purl.uniprot.org/core/author | "Ellisman M.H."xsd:string |
| http://purl.uniprot.org/citations/12689591 | http://purl.uniprot.org/core/author | "Jones Y."xsd:string |
| http://purl.uniprot.org/citations/12689591 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12689591 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/12689591 | http://purl.uniprot.org/core/pages | "521-533"xsd:string |
| http://purl.uniprot.org/citations/12689591 | http://purl.uniprot.org/core/title | "JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins."xsd:string |
| http://purl.uniprot.org/citations/12689591 | http://purl.uniprot.org/core/volume | "4"xsd:string |
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