| http://purl.uniprot.org/citations/12690206 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12690206 | http://www.w3.org/2000/01/rdf-schema#comment | "Signaling from the DAF-2/insulin receptor to the DAF-16/FOXO transcription factor controls longevity, metabolism, and development in disparate phyla. To identify genes that mediate the conserved biological outputs of daf-2/insulin-like signaling, we used comparative genomics to identify 17 orthologous genes from Caenorhabditis and Drosophila, each of which bears a DAF-16 binding site in the promoter region. One-third of these DAF-16 downstream candidate genes were regulated by daf-2/insulin-like signaling in C. elegans, and RNA interference inactivation of the candidates showed that many of these genes mediate distinct aspects of daf-16 function, including longevity, metabolism, and development."xsd:string |
| http://purl.uniprot.org/citations/12690206 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1083614"xsd:string |
| http://purl.uniprot.org/citations/12690206 | http://purl.uniprot.org/core/author | "Lee S.S."xsd:string |
| http://purl.uniprot.org/citations/12690206 | http://purl.uniprot.org/core/author | "Kennedy S."xsd:string |
| http://purl.uniprot.org/citations/12690206 | http://purl.uniprot.org/core/author | "Ruvkun G."xsd:string |
| http://purl.uniprot.org/citations/12690206 | http://purl.uniprot.org/core/author | "Tolonen A.C."xsd:string |
| http://purl.uniprot.org/citations/12690206 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12690206 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/12690206 | http://purl.uniprot.org/core/pages | "644-647"xsd:string |
| http://purl.uniprot.org/citations/12690206 | http://purl.uniprot.org/core/title | "DAF-16 target genes that control C. elegans life-span and metabolism."xsd:string |
| http://purl.uniprot.org/citations/12690206 | http://purl.uniprot.org/core/volume | "300"xsd:string |
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| http://purl.uniprot.org/uniprot/#_Q22633-mappedCitation-12690206 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12690206 |
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