| http://purl.uniprot.org/citations/12692549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12692549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12692549 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcription factors interferon regulatory factor 3 (IRF3) and NF-kappaB are required for the expression of many genes involved in the innate immune response. Viral infection, or the binding of double-stranded RNA to Toll-like receptor 3, results in the coordinate activation of IRF3 and NF-kappaB. Activation of IRF3 requires signal-dependent phosphorylation, but little is known about the signaling pathway or kinases involved. Here we report that the noncanonical IkappaB kinase homologs, IkappaB kinase-epsilon (IKKepsilon) and TANK-binding kinase-1 (TBK1), which were previously implicated in NF-kappaB activation, are also essential components of the IRF3 signaling pathway. Thus, IKKepsilon and TBK1 have a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response."xsd:string |
| http://purl.uniprot.org/citations/12692549 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni921"xsd:string |
| http://purl.uniprot.org/citations/12692549 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni921"xsd:string |
| http://purl.uniprot.org/citations/12692549 | http://purl.uniprot.org/core/author | "McWhirter S.M."xsd:string |
| http://purl.uniprot.org/citations/12692549 | http://purl.uniprot.org/core/author | "McWhirter S.M."xsd:string |
| http://purl.uniprot.org/citations/12692549 | http://purl.uniprot.org/core/author | "Maniatis T."xsd:string |
| http://purl.uniprot.org/citations/12692549 | http://purl.uniprot.org/core/author | "Maniatis T."xsd:string |
| http://purl.uniprot.org/citations/12692549 | http://purl.uniprot.org/core/author | "Fitzgerald K.A."xsd:string |
| http://purl.uniprot.org/citations/12692549 | http://purl.uniprot.org/core/author | "Fitzgerald K.A."xsd:string |
| http://purl.uniprot.org/citations/12692549 | http://purl.uniprot.org/core/author | "Latz E."xsd:string |
| http://purl.uniprot.org/citations/12692549 | http://purl.uniprot.org/core/author | "Latz E."xsd:string |
| http://purl.uniprot.org/citations/12692549 | http://purl.uniprot.org/core/author | "Golenbock D.T."xsd:string |
| http://purl.uniprot.org/citations/12692549 | http://purl.uniprot.org/core/author | "Golenbock D.T."xsd:string |
| http://purl.uniprot.org/citations/12692549 | http://purl.uniprot.org/core/author | "Coyle A.J."xsd:string |
| http://purl.uniprot.org/citations/12692549 | http://purl.uniprot.org/core/author | "Coyle A.J."xsd:string |
| http://purl.uniprot.org/citations/12692549 | http://purl.uniprot.org/core/author | "Liao S.-M."xsd:string |
| http://purl.uniprot.org/citations/12692549 | http://purl.uniprot.org/core/author | "Liao S.-M."xsd:string |
| http://purl.uniprot.org/citations/12692549 | http://purl.uniprot.org/core/author | "Rowe D.C."xsd:string |
| http://purl.uniprot.org/citations/12692549 | http://purl.uniprot.org/core/author | "Rowe D.C."xsd:string |
| http://purl.uniprot.org/citations/12692549 | http://purl.uniprot.org/core/author | "Faia K.L."xsd:string |
| http://purl.uniprot.org/citations/12692549 | http://purl.uniprot.org/core/author | "Faia K.L."xsd:string |
| http://purl.uniprot.org/citations/12692549 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12692549 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |