| http://purl.uniprot.org/citations/12694387 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12694387 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12694387 | http://www.w3.org/2000/01/rdf-schema#comment | "A new class of Conus peptides, the I-superfamily of conotoxins, has been characterized using biochemical, electrophysiological and molecular genetic methods. Peptides in this superfamily have a novel pattern of eight Cys residues. Five peptides that elicited excitatory symptomatology, r11a, r11b, r11c, r11d and r11e, were purified from Conus radiatus venom; four were tested on amphibian peripheral axons and shown to elicit repetitive action potentials, consistent with being members of the 'lightning-strike cabal' of toxins that effect instant immobilization of fish prey. A parallel analysis of Conus cDNA clones revealed a new class of conotoxin genes that was particularly enriched (with 18 identified paralogues) in a Conus radiatus venom duct library; several C. radiatus clones encoded the excitatory peptides directly characterized from venom. The remarkable diversity of related I-superfamily peptides within a single Conus species is unprecedented. When combined with the excitatory effects observed on peripheral circuitry, this unexpected diversity suggests a corresponding molecular complexity of the targeted signaling components in peripheral axons; the I-conotoxin superfamily should provide a rich lode of pharmacological tools for dissecting and understanding these. Thus, the I-superfamily conotoxins promise to provide a significant new technology platform for dissecting the molecular components of axons."xsd:string |
| http://purl.uniprot.org/citations/12694387 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1471-4159.2003.01685.x"xsd:string |
| http://purl.uniprot.org/citations/12694387 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1471-4159.2003.01685.x"xsd:string |
| http://purl.uniprot.org/citations/12694387 | http://purl.uniprot.org/core/author | "Walker C."xsd:string |
| http://purl.uniprot.org/citations/12694387 | http://purl.uniprot.org/core/author | "Walker C."xsd:string |
| http://purl.uniprot.org/citations/12694387 | http://purl.uniprot.org/core/author | "Olivera B.M."xsd:string |
| http://purl.uniprot.org/citations/12694387 | http://purl.uniprot.org/core/author | "Olivera B.M."xsd:string |
| http://purl.uniprot.org/citations/12694387 | http://purl.uniprot.org/core/author | "Cruz L.J."xsd:string |
| http://purl.uniprot.org/citations/12694387 | http://purl.uniprot.org/core/author | "Cruz L.J."xsd:string |
| http://purl.uniprot.org/citations/12694387 | http://purl.uniprot.org/core/author | "Abogadie F.C."xsd:string |
| http://purl.uniprot.org/citations/12694387 | http://purl.uniprot.org/core/author | "Abogadie F.C."xsd:string |
| http://purl.uniprot.org/citations/12694387 | http://purl.uniprot.org/core/author | "Jimenez E.C."xsd:string |
| http://purl.uniprot.org/citations/12694387 | http://purl.uniprot.org/core/author | "Jimenez E.C."xsd:string |
| http://purl.uniprot.org/citations/12694387 | http://purl.uniprot.org/core/author | "Rivier J."xsd:string |
| http://purl.uniprot.org/citations/12694387 | http://purl.uniprot.org/core/author | "Rivier J."xsd:string |
| http://purl.uniprot.org/citations/12694387 | http://purl.uniprot.org/core/author | "Yoshikami D."xsd:string |
| http://purl.uniprot.org/citations/12694387 | http://purl.uniprot.org/core/author | "Yoshikami D."xsd:string |
| http://purl.uniprot.org/citations/12694387 | http://purl.uniprot.org/core/author | "Lirazan M."xsd:string |
| http://purl.uniprot.org/citations/12694387 | http://purl.uniprot.org/core/author | "Lirazan M."xsd:string |
| http://purl.uniprot.org/citations/12694387 | http://purl.uniprot.org/core/author | "Shetty R.P."xsd:string |
| http://purl.uniprot.org/citations/12694387 | http://purl.uniprot.org/core/author | "Shetty R.P."xsd:string |
| http://purl.uniprot.org/citations/12694387 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12694387 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |