| http://purl.uniprot.org/citations/12695491 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12695491 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin (IL)-18 synergizes with IL-12 to promote T helper cell (Th)1 responses. Somewhat paradoxically, IL-18 administration alone strongly induces immunoglobulin (Ig)E production and allergic inflammation, indicating a role for IL-18 in the generation of Th2 responses. The ability of IL-18 to induce IgE is dependent on CD4+ T cells, IL-4, and signal transducer and activator of transcription (stat)6. Here, we show that IL-18 fails to induce IgE both in CD1d-/- mice that lack natural killer T (NKT) cells and in class II-/-mice that lack conventional CD4+ T cells. However, class II-/-mice reconstituted with conventional CD4+ T cells show the capacity to produce IgE in response to IL-18. NKT cells express high levels of IL-18 receptor (R)alpha chain and produce significant amounts of IL-4, IL-9, and IL-13, and induce CD40 ligand expression in response to IL-2 and IL-18 stimulation in vitro. In contrast, conventional CD4+ T cells express low levels of IL-18Ralpha and poorly respond to IL-2 and IL-18. Nevertheless, conventional CD4+ T cells are essential for B cell IgE responses after the administration of IL-18. These findings indicate that NKT cells might be the major source of IL-4 in response to IL-18 administration and that conventional CD4+ T cells demonstrate their helper function in the presence of NKT cells."xsd:string |
| http://purl.uniprot.org/citations/12695491 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20021701"xsd:string |
| http://purl.uniprot.org/citations/12695491 | http://purl.uniprot.org/core/author | "Hayashi N."xsd:string |
| http://purl.uniprot.org/citations/12695491 | http://purl.uniprot.org/core/author | "Hata H."xsd:string |
| http://purl.uniprot.org/citations/12695491 | http://purl.uniprot.org/core/author | "Ishikawa Y."xsd:string |
| http://purl.uniprot.org/citations/12695491 | http://purl.uniprot.org/core/author | "Okumura K."xsd:string |
| http://purl.uniprot.org/citations/12695491 | http://purl.uniprot.org/core/author | "Sasaki Y."xsd:string |
| http://purl.uniprot.org/citations/12695491 | http://purl.uniprot.org/core/author | "Takeda K."xsd:string |
| http://purl.uniprot.org/citations/12695491 | http://purl.uniprot.org/core/author | "Yoshimoto T."xsd:string |
| http://purl.uniprot.org/citations/12695491 | http://purl.uniprot.org/core/author | "Min B."xsd:string |
| http://purl.uniprot.org/citations/12695491 | http://purl.uniprot.org/core/author | "Nakanishi K."xsd:string |
| http://purl.uniprot.org/citations/12695491 | http://purl.uniprot.org/core/author | "Sugimoto T."xsd:string |
| http://purl.uniprot.org/citations/12695491 | http://purl.uniprot.org/core/author | "Paul W.E."xsd:string |
| http://purl.uniprot.org/citations/12695491 | http://purl.uniprot.org/core/author | "Van Kaer L."xsd:string |
| http://purl.uniprot.org/citations/12695491 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12695491 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/12695491 | http://purl.uniprot.org/core/pages | "997-1005"xsd:string |
| http://purl.uniprot.org/citations/12695491 | http://purl.uniprot.org/core/title | "Nonredundant roles for CD1d-restricted natural killer T cells and conventional CD4+ T cells in the induction of immunoglobulin E antibodies in response to interleukin 18 treatment of mice."xsd:string |
| http://purl.uniprot.org/citations/12695491 | http://purl.uniprot.org/core/volume | "197"xsd:string |
| http://purl.uniprot.org/citations/12695491 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12695491 |
| http://purl.uniprot.org/citations/12695491 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12695491 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B3-mappedCitation-12695491 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12695491 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J090-mappedCitation-12695491 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12695491 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G5-mappedCitation-12695491 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12695491 |