| http://purl.uniprot.org/citations/12697763 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12697763 | http://www.w3.org/2000/01/rdf-schema#comment | "It was previously reported that Cbl-b associates with Crk-L in Jurkat T cells. However, the physiological significance of such association remains unclear. Here we examined a regulatory role of Cbl-b in Crk-L-C3G signaling pathway. We found that Cbl-b associates with, and induces, ubiquitin conjugation to Crk-L, which requires a functional RING finger. Cbl-b deficiency does not affect Crk-L stability, but its association with C3G. In Cbl-b-/-T cells, the interaction between Crk-L and C3G, and the activity of the small GTPase Rap1, are increased. Cbl-b-/-T cells also display increased adhesion and cell surface binding to ICAM-1, a finding that is supported by the enhanced clustering of LFA-1 in Cbl-b-/-T cells in response to TCR stimulation. Thus, Cbl-b plays a negative role in Crk-L-C3G-mediated Rap1 and LFA-1 activation in T cells."xsd:string |
| http://purl.uniprot.org/citations/12697763 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m212671200"xsd:string |
| http://purl.uniprot.org/citations/12697763 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/12697763 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/12697763 | http://purl.uniprot.org/core/author | "Shao Y."xsd:string |
| http://purl.uniprot.org/citations/12697763 | http://purl.uniprot.org/core/author | "Fang D."xsd:string |
| http://purl.uniprot.org/citations/12697763 | http://purl.uniprot.org/core/author | "Liu Y.C."xsd:string |
| http://purl.uniprot.org/citations/12697763 | http://purl.uniprot.org/core/author | "Jeon M.S."xsd:string |
| http://purl.uniprot.org/citations/12697763 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12697763 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12697763 | http://purl.uniprot.org/core/pages | "23978-23983"xsd:string |
| http://purl.uniprot.org/citations/12697763 | http://purl.uniprot.org/core/title | "Negative regulation of T cell antigen receptor-mediated Crk-L-C3G signaling and cell adhesion by Cbl-b."xsd:string |
| http://purl.uniprot.org/citations/12697763 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12697763 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12697763 |
| http://purl.uniprot.org/citations/12697763 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12697763 |
| http://purl.uniprot.org/uniprot/Q3TTA7#attribution-9C460A0ABC905248A9E7EBEB5644DF9F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12697763 |
| http://purl.uniprot.org/uniprot/Q3TTA7#attribution-AB29B403049765351423E803EA1D5F11 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12697763 |
| http://purl.uniprot.org/uniprot/#_A0A087WQ05-mappedCitation-12697763 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12697763 |
| http://purl.uniprot.org/uniprot/#_A1L338-mappedCitation-12697763 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12697763 |
| http://purl.uniprot.org/uniprot/#_A0A1S5UYZ7-mappedCitation-12697763 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12697763 |
| http://purl.uniprot.org/uniprot/#_A0A5F8MPI9-mappedCitation-12697763 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12697763 |
| http://purl.uniprot.org/uniprot/#_A0A338P6Q0-mappedCitation-12697763 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12697763 |
| http://purl.uniprot.org/uniprot/#_A0A338P675-mappedCitation-12697763 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12697763 |
| http://purl.uniprot.org/uniprot/#_A2RS58-mappedCitation-12697763 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12697763 |