| http://purl.uniprot.org/citations/12700595 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12700595 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12700595 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-22 (IL-22), a member of IL-10 family, plays some important roles in immune response through activation of the STAT 3 signal transduction pathway. Two types of IL-22-binding receptor have been discovered, a membrane-bound receptor and a soluble receptor, both encoded by different genes. IL-22 may be involved in inflammatory processes specifically regulated by soluble receptors. By screening a mouse genomic library for a human IL-22 binding protein homologue, we identified the mouse genomic clone of IL-22 binding protein. Its coding sequence was verified and isolated by RT-PCR. The gene encodes a protein of 230 amino acids that share 67.1% amino-acid sequence identity with human IL-22 binding protein. We designated this receptor 'mouse IL-22 binding protein' (mIL-22BP). mIL-22BP could be upregulated by LPS stimulation in mouse monocytes. mIL-22BP binds to mouse and human IL-22 and neutralizes STAT3 activation induced by both cytokines in human and rat hepatoma cell lines. Treating B cells with mouse IL-22 induces production of reactive oxygen species, which mIL-22BP blocks."xsd:string |
| http://purl.uniprot.org/citations/12700595 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.gene.6363947"xsd:string |
| http://purl.uniprot.org/citations/12700595 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.gene.6363947"xsd:string |
| http://purl.uniprot.org/citations/12700595 | http://purl.uniprot.org/core/author | "Chang M.-S."xsd:string |
| http://purl.uniprot.org/citations/12700595 | http://purl.uniprot.org/core/author | "Chang M.-S."xsd:string |
| http://purl.uniprot.org/citations/12700595 | http://purl.uniprot.org/core/author | "Chen G.-Y."xsd:string |
| http://purl.uniprot.org/citations/12700595 | http://purl.uniprot.org/core/author | "Chen G.-Y."xsd:string |
| http://purl.uniprot.org/citations/12700595 | http://purl.uniprot.org/core/author | "Ho T.-W."xsd:string |
| http://purl.uniprot.org/citations/12700595 | http://purl.uniprot.org/core/author | "Ho T.-W."xsd:string |
| http://purl.uniprot.org/citations/12700595 | http://purl.uniprot.org/core/author | "Liang W.-G."xsd:string |
| http://purl.uniprot.org/citations/12700595 | http://purl.uniprot.org/core/author | "Liang W.-G."xsd:string |
| http://purl.uniprot.org/citations/12700595 | http://purl.uniprot.org/core/author | "Wei C.-C."xsd:string |
| http://purl.uniprot.org/citations/12700595 | http://purl.uniprot.org/core/author | "Wei C.-C."xsd:string |
| http://purl.uniprot.org/citations/12700595 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12700595 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12700595 | http://purl.uniprot.org/core/name | "Genes Immun."xsd:string |
| http://purl.uniprot.org/citations/12700595 | http://purl.uniprot.org/core/name | "Genes Immun."xsd:string |
| http://purl.uniprot.org/citations/12700595 | http://purl.uniprot.org/core/pages | "204-211"xsd:string |
| http://purl.uniprot.org/citations/12700595 | http://purl.uniprot.org/core/pages | "204-211"xsd:string |
| http://purl.uniprot.org/citations/12700595 | http://purl.uniprot.org/core/title | "Cloning and characterization of mouse IL-22 binding protein."xsd:string |
| http://purl.uniprot.org/citations/12700595 | http://purl.uniprot.org/core/title | "Cloning and characterization of mouse IL-22 binding protein."xsd:string |
| http://purl.uniprot.org/citations/12700595 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/12700595 | http://purl.uniprot.org/core/volume | "4"xsd:string |