| http://purl.uniprot.org/citations/12702658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12702658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12702658 | http://www.w3.org/2000/01/rdf-schema#comment | "Sphingosine-1-phosphate is a sphingolipid metabolite that regulates cell proliferation, migration and apoptosis through specific signaling pathways. Sphingosine-1-phosphate lyase catalyzes the conversion of sphingosine-1-phosphate to ethanolamine phosphate and a fatty aldehyde. We report the cloning of the Drosophila sphingosine-1-phosphate lyase gene (Sply) and demonstrate its importance for adult muscle development and integrity, reproduction and larval viability. Sply expression is temporally regulated, with onset of expression during mid-embryogenesis. Sply null mutants accumulate both phosphorylated and unphosphorylated sphingoid bases and exhibit semi-lethality, increased apoptosis in developing embryos, diminished egg-laying, and gross pattern abnormalities in dorsal longitudinal flight muscles. These defects are corrected by restoring Sply expression or by introduction of a suppressor mutation that diminishes sphingolipid synthesis and accumulation of sphingolipid intermediates. This is the first demonstration of novel and complex developmental pathologies directly linked to a disruption of sphingolipid catabolism in metazoans."xsd:string |
| http://purl.uniprot.org/citations/12702658 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.00456"xsd:string |
| http://purl.uniprot.org/citations/12702658 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.00456"xsd:string |
| http://purl.uniprot.org/citations/12702658 | http://purl.uniprot.org/core/author | "Saba J.D."xsd:string |
| http://purl.uniprot.org/citations/12702658 | http://purl.uniprot.org/core/author | "Saba J.D."xsd:string |
| http://purl.uniprot.org/citations/12702658 | http://purl.uniprot.org/core/author | "Fyrst H."xsd:string |
| http://purl.uniprot.org/citations/12702658 | http://purl.uniprot.org/core/author | "Fyrst H."xsd:string |
| http://purl.uniprot.org/citations/12702658 | http://purl.uniprot.org/core/author | "Harris G.L."xsd:string |
| http://purl.uniprot.org/citations/12702658 | http://purl.uniprot.org/core/author | "Harris G.L."xsd:string |
| http://purl.uniprot.org/citations/12702658 | http://purl.uniprot.org/core/author | "Georges R."xsd:string |
| http://purl.uniprot.org/citations/12702658 | http://purl.uniprot.org/core/author | "Georges R."xsd:string |
| http://purl.uniprot.org/citations/12702658 | http://purl.uniprot.org/core/author | "Heinecke K."xsd:string |
| http://purl.uniprot.org/citations/12702658 | http://purl.uniprot.org/core/author | "Heinecke K."xsd:string |
| http://purl.uniprot.org/citations/12702658 | http://purl.uniprot.org/core/author | "Herr D.R."xsd:string |
| http://purl.uniprot.org/citations/12702658 | http://purl.uniprot.org/core/author | "Herr D.R."xsd:string |
| http://purl.uniprot.org/citations/12702658 | http://purl.uniprot.org/core/author | "Phan V."xsd:string |
| http://purl.uniprot.org/citations/12702658 | http://purl.uniprot.org/core/author | "Phan V."xsd:string |
| http://purl.uniprot.org/citations/12702658 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12702658 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12702658 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/12702658 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/12702658 | http://purl.uniprot.org/core/pages | "2443-2453"xsd:string |
| http://purl.uniprot.org/citations/12702658 | http://purl.uniprot.org/core/pages | "2443-2453"xsd:string |