| http://purl.uniprot.org/citations/12702762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12702762 | http://www.w3.org/2000/01/rdf-schema#comment | "Glucagon-like peptide (GLP) 1 is produced through posttranslational processing of proglucagon and acts as a regulator of various homeostatic events. Among its analogs, however, the function of GLP-1-(1-37), synthesized in small amounts in the pancreas, has been unclear. Here, we find that GLP-1-(1-37) induces insulin production in developing and, to a lesser extent, adult intestinal epithelial cells in vitro and in vivo, a process mediated by up-regulation of the Notch-related gene ngn3 and its downstream targets, which are involved in pancreatic endocrine differentiation. These cells became responsive to glucose challenge in vitro and reverse insulin-dependent diabetes after implantation into diabetic mice. Our findings suggest that efficient induction of insulin production in intestinal epithelial cells by GLP-1-(1-37) could represent a new therapeutic approach to diabetes mellitus."xsd:string |
| http://purl.uniprot.org/citations/12702762 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0936260100"xsd:string |
| http://purl.uniprot.org/citations/12702762 | http://purl.uniprot.org/core/author | "Nakauchi H."xsd:string |
| http://purl.uniprot.org/citations/12702762 | http://purl.uniprot.org/core/author | "Taniguchi H."xsd:string |
| http://purl.uniprot.org/citations/12702762 | http://purl.uniprot.org/core/author | "Suzuki A."xsd:string |
| http://purl.uniprot.org/citations/12702762 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12702762 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/12702762 | http://purl.uniprot.org/core/pages | "5034-5039"xsd:string |
| http://purl.uniprot.org/citations/12702762 | http://purl.uniprot.org/core/title | "Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells."xsd:string |
| http://purl.uniprot.org/citations/12702762 | http://purl.uniprot.org/core/volume | "100"xsd:string |
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| http://purl.uniprot.org/uniprot/#_D3YWU5-mappedCitation-12702762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12702762 |
| http://purl.uniprot.org/uniprot/#_D3Z595-mappedCitation-12702762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12702762 |
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