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http://purl.uniprot.org/citations/12702806http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12702806http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12702806http://www.w3.org/2000/01/rdf-schema#comment"Rapid induction of type I interferon expression, a central event in establishing the innate antiviral response, requires cooperative activation of numerous transcription factors. Although signaling pathways that activate the transcription factors nuclear factor kappaB and ATF-2/c-Jun have been well characterized, activation of the interferon regulatory factors IRF-3 and IRF-7 has remained a critical missing link in understanding interferon signaling. We report here that the IkappaB kinase (IKK)-related kinases IKKepsilon and TANK-binding kinase 1 are components of the virus-activated kinase that phosphorylate IRF-3 and IRF-7. These studies illustrate an essential role for an IKK-related kinase pathway in triggering the host antiviral response to viral infection."xsd:string
http://purl.uniprot.org/citations/12702806http://purl.org/dc/terms/identifier"doi:10.1126/science.1081315"xsd:string
http://purl.uniprot.org/citations/12702806http://purl.org/dc/terms/identifier"doi:10.1126/science.1081315"xsd:string
http://purl.uniprot.org/citations/12702806http://purl.uniprot.org/core/author"Lin R."xsd:string
http://purl.uniprot.org/citations/12702806http://purl.uniprot.org/core/author"Lin R."xsd:string
http://purl.uniprot.org/citations/12702806http://purl.uniprot.org/core/author"Sharma S."xsd:string
http://purl.uniprot.org/citations/12702806http://purl.uniprot.org/core/author"Sharma S."xsd:string
http://purl.uniprot.org/citations/12702806http://purl.uniprot.org/core/author"Hiscott J."xsd:string
http://purl.uniprot.org/citations/12702806http://purl.uniprot.org/core/author"Hiscott J."xsd:string
http://purl.uniprot.org/citations/12702806http://purl.uniprot.org/core/author"Grandvaux N."xsd:string
http://purl.uniprot.org/citations/12702806http://purl.uniprot.org/core/author"Grandvaux N."xsd:string
http://purl.uniprot.org/citations/12702806http://purl.uniprot.org/core/author"tenOever B.R."xsd:string
http://purl.uniprot.org/citations/12702806http://purl.uniprot.org/core/author"tenOever B.R."xsd:string
http://purl.uniprot.org/citations/12702806http://purl.uniprot.org/core/author"Zhou G.-P."xsd:string
http://purl.uniprot.org/citations/12702806http://purl.uniprot.org/core/author"Zhou G.-P."xsd:string
http://purl.uniprot.org/citations/12702806http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/12702806http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/12702806http://purl.uniprot.org/core/name"Science"xsd:string
http://purl.uniprot.org/citations/12702806http://purl.uniprot.org/core/name"Science"xsd:string
http://purl.uniprot.org/citations/12702806http://purl.uniprot.org/core/pages"1148-1151"xsd:string
http://purl.uniprot.org/citations/12702806http://purl.uniprot.org/core/pages"1148-1151"xsd:string
http://purl.uniprot.org/citations/12702806http://purl.uniprot.org/core/title"Triggering the interferon antiviral response through an IKK-related pathway."xsd:string
http://purl.uniprot.org/citations/12702806http://purl.uniprot.org/core/title"Triggering the interferon antiviral response through an IKK-related pathway."xsd:string