| http://purl.uniprot.org/citations/12707323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12707323 | http://www.w3.org/2000/01/rdf-schema#comment | "The signaling pathways that control T cell differentiation have only begun to be elucidated. Using T cell lines, it has been shown that class IA phosphatidylinositol 3-kinase (PI3K), a heterodimer composed of a p85 regulatory and a p110 catalytic subunit, is activated after TCR stimulation. Nonetheless, the contribution of p85/p110 PI3K isoforms in T cell development has not been described. Mice deficient in the other family of class I PI3K, p110gamma, which is regulated by G protein-coupled receptors, exhibit reduced thymus size. Here we examine T cell development in p110gamma-deficient mice and in mice expressing an activating mutation of the p85 regulatory subunit, p65(PI3K), in T cells. We show that p110gamma-deficient mice have a partial defect in pre-TCR-dependent differentiation, which is restored after expression of the p65(PI3K) activating mutation. Genetic alteration of both PI3K isoforms also affects positive selection; p110gamma deletion decreased and p65(PI3K) expression augmented the CD4(+)/CD8(+) differentiation ratio. Finally, data are presented showing that both PI3K isoforms influenced mature thymocyte migration to the periphery. These observations underscore the contribution of PI3K in T cell development, as well as its implication in determining the CD4(+)/CD8(+) T cell differentiation ratio in vivo."xsd:string |
| http://purl.uniprot.org/citations/12707323 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.170.9.4475"xsd:string |
| http://purl.uniprot.org/citations/12707323 | http://purl.uniprot.org/core/author | "Hirsch E."xsd:string |
| http://purl.uniprot.org/citations/12707323 | http://purl.uniprot.org/core/author | "Sanchez A."xsd:string |
| http://purl.uniprot.org/citations/12707323 | http://purl.uniprot.org/core/author | "Hernandez C."xsd:string |
| http://purl.uniprot.org/citations/12707323 | http://purl.uniprot.org/core/author | "Martinez-A C."xsd:string |
| http://purl.uniprot.org/citations/12707323 | http://purl.uniprot.org/core/author | "Carrera A.C."xsd:string |
| http://purl.uniprot.org/citations/12707323 | http://purl.uniprot.org/core/author | "Barber D.F."xsd:string |
| http://purl.uniprot.org/citations/12707323 | http://purl.uniprot.org/core/author | "Wymann M."xsd:string |
| http://purl.uniprot.org/citations/12707323 | http://purl.uniprot.org/core/author | "Rodriguez-Borlado L."xsd:string |
| http://purl.uniprot.org/citations/12707323 | http://purl.uniprot.org/core/author | "Rodriguez-Marcos M.A."xsd:string |
| http://purl.uniprot.org/citations/12707323 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12707323 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/12707323 | http://purl.uniprot.org/core/pages | "4475-4482"xsd:string |
| http://purl.uniprot.org/citations/12707323 | http://purl.uniprot.org/core/title | "Phosphatidylinositol 3-kinase regulates the CD4/CD8 T cell differentiation ratio."xsd:string |
| http://purl.uniprot.org/citations/12707323 | http://purl.uniprot.org/core/volume | "170"xsd:string |
| http://purl.uniprot.org/citations/12707323 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12707323 |
| http://purl.uniprot.org/citations/12707323 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12707323 |
| http://purl.uniprot.org/uniprot/Q3U6Q4#attribution-D7A366BB50FA30672E30049C80A749AD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12707323 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P8F6-mappedCitation-12707323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12707323 |
| http://purl.uniprot.org/uniprot/#_Q24LN5-mappedCitation-12707323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12707323 |
| http://purl.uniprot.org/uniprot/#_Q3UVA4-mappedCitation-12707323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12707323 |
| http://purl.uniprot.org/uniprot/#_Q3V1C0-mappedCitation-12707323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12707323 |
| http://purl.uniprot.org/uniprot/#_Q3U6Q4-mappedCitation-12707323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12707323 |