| http://purl.uniprot.org/citations/12708471 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12708471 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12708471 | http://www.w3.org/2000/01/rdf-schema#comment | "Aberrant glycosylation occurs during development of gastric carcinomas. The initiation of mucin-type O-glycosylation is regulated by GalNAc-T3 (UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase-3). However, the clinical significance of GalNAc-T3 expression in human gastric carcinoma has not yet been demonstrated. In the present study, we investigated the relationship between immunohistochemical GalNAc-T3 expression and various clinicopathologic factors, including prognosis, in 117 gastric carcinoma patients. Of 117 gastric carcinomas examined, 59 (50.4%) showed strong expression of GalNAc-T3. Strong expression was detected in 38 of 59 (64.4%) differentiated type and in 21 of 58 (36.2%) undifferentiated gastric carcinomas, indicating that the expression of GalNAc-T3 correlated significantly with tumor differentiation (P=0.0023, chi2 test). Overall 5-year survival rate in patients with strong GalNAc-T3 expression (71.0%) was significantly better than that of patients with weak expression (49.3%) (P=0.0197, log-rank test). Multivariate analysis identified GalNAc-T3 expression as an independent prognostic factor (P=0.0158, Cox proportional hazards model). Our data suggest that GalNAc-T3 expression may be a useful marker for prognosis and differentiation of gastric carcinomas."xsd:string |
| http://purl.uniprot.org/citations/12708471 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1349-7006.2003.tb01348.x"xsd:string |
| http://purl.uniprot.org/citations/12708471 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1349-7006.2003.tb01348.x"xsd:string |
| http://purl.uniprot.org/citations/12708471 | http://purl.uniprot.org/core/author | "Kohno K."xsd:string |
| http://purl.uniprot.org/citations/12708471 | http://purl.uniprot.org/core/author | "Kohno K."xsd:string |
| http://purl.uniprot.org/citations/12708471 | http://purl.uniprot.org/core/author | "Itoh H."xsd:string |
| http://purl.uniprot.org/citations/12708471 | http://purl.uniprot.org/core/author | "Itoh H."xsd:string |
| http://purl.uniprot.org/citations/12708471 | http://purl.uniprot.org/core/author | "Matsuo K."xsd:string |
| http://purl.uniprot.org/citations/12708471 | http://purl.uniprot.org/core/author | "Matsuo K."xsd:string |
| http://purl.uniprot.org/citations/12708471 | http://purl.uniprot.org/core/author | "Hirata K."xsd:string |
| http://purl.uniprot.org/citations/12708471 | http://purl.uniprot.org/core/author | "Hirata K."xsd:string |
| http://purl.uniprot.org/citations/12708471 | http://purl.uniprot.org/core/author | "Minagawa N."xsd:string |
| http://purl.uniprot.org/citations/12708471 | http://purl.uniprot.org/core/author | "Minagawa N."xsd:string |
| http://purl.uniprot.org/citations/12708471 | http://purl.uniprot.org/core/author | "Nakayama Y."xsd:string |
| http://purl.uniprot.org/citations/12708471 | http://purl.uniprot.org/core/author | "Nakayama Y."xsd:string |
| http://purl.uniprot.org/citations/12708471 | http://purl.uniprot.org/core/author | "Nagata N."xsd:string |
| http://purl.uniprot.org/citations/12708471 | http://purl.uniprot.org/core/author | "Nagata N."xsd:string |
| http://purl.uniprot.org/citations/12708471 | http://purl.uniprot.org/core/author | "Kitazato K."xsd:string |
| http://purl.uniprot.org/citations/12708471 | http://purl.uniprot.org/core/author | "Kitazato K."xsd:string |
| http://purl.uniprot.org/citations/12708471 | http://purl.uniprot.org/core/author | "Izumi H."xsd:string |
| http://purl.uniprot.org/citations/12708471 | http://purl.uniprot.org/core/author | "Izumi H."xsd:string |
| http://purl.uniprot.org/citations/12708471 | http://purl.uniprot.org/core/author | "Onitsuka K."xsd:string |
| http://purl.uniprot.org/citations/12708471 | http://purl.uniprot.org/core/author | "Onitsuka K."xsd:string |