| http://purl.uniprot.org/citations/12709403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12709403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12709403 | http://www.w3.org/2000/01/rdf-schema#comment | "Ubiquinone (coenzyme Q; Q) is a key factor in the mitochondria electron transport chain, but it also functions as an antioxidant and as a cofactor of mitochondrial uncoupling proteins. Furthermore, Q isoforms balance in Caenorhabditis elegans is determined by both dietary intake and endogenous biosynthesis. In the absence of synthesis, withdrawal of dietary Q8 in adulthood extends life span. Thus, Q plays an important role in the aging process and understanding its synthesis acquires a new impetus. We have identified by RNA interference (RNAi) eight genes, including clk-1, involved in ubiquinone biosynthesis in C. elegans feeding animals with dsRNA-containing Escherichia coli HT115 strains. Silenced C. elegans showed lower levels of both endogenous Q9 and Q8 provided by diet, produced less superoxide without a significant modification of mitochondrial electron chain, and extended life span compared with non-interfered animals. E. coli strains harboring dsRNA also interfered with their own Q8 biosynthesis. These findings suggest that more efficient electron transport between a lower amount of Q and electron transport capacity of the mitochondrial complexes leads to less production of reactive oxygen species that contributes to extension of life span in the nematode C. elegans."xsd:string |
| http://purl.uniprot.org/citations/12709403 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.02-1022fje"xsd:string |
| http://purl.uniprot.org/citations/12709403 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.02-1022fje"xsd:string |
| http://purl.uniprot.org/citations/12709403 | http://purl.uniprot.org/core/author | "Navas P."xsd:string |
| http://purl.uniprot.org/citations/12709403 | http://purl.uniprot.org/core/author | "Navas P."xsd:string |
| http://purl.uniprot.org/citations/12709403 | http://purl.uniprot.org/core/author | "Rodriguez-Aguilera J.C."xsd:string |
| http://purl.uniprot.org/citations/12709403 | http://purl.uniprot.org/core/author | "Rodriguez-Aguilera J.C."xsd:string |
| http://purl.uniprot.org/citations/12709403 | http://purl.uniprot.org/core/author | "Asencio C."xsd:string |
| http://purl.uniprot.org/citations/12709403 | http://purl.uniprot.org/core/author | "Asencio C."xsd:string |
| http://purl.uniprot.org/citations/12709403 | http://purl.uniprot.org/core/author | "Ruiz-Ferrer M."xsd:string |
| http://purl.uniprot.org/citations/12709403 | http://purl.uniprot.org/core/author | "Ruiz-Ferrer M."xsd:string |
| http://purl.uniprot.org/citations/12709403 | http://purl.uniprot.org/core/author | "Vela J."xsd:string |
| http://purl.uniprot.org/citations/12709403 | http://purl.uniprot.org/core/author | "Vela J."xsd:string |
| http://purl.uniprot.org/citations/12709403 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12709403 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12709403 | http://purl.uniprot.org/core/name | "FASEB J."xsd:string |
| http://purl.uniprot.org/citations/12709403 | http://purl.uniprot.org/core/name | "FASEB J."xsd:string |
| http://purl.uniprot.org/citations/12709403 | http://purl.uniprot.org/core/pages | "1135-1137"xsd:string |
| http://purl.uniprot.org/citations/12709403 | http://purl.uniprot.org/core/pages | "1135-1137"xsd:string |
| http://purl.uniprot.org/citations/12709403 | http://purl.uniprot.org/core/title | "Silencing of ubiquinone biosynthesis genes extends life span in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/12709403 | http://purl.uniprot.org/core/title | "Silencing of ubiquinone biosynthesis genes extends life span in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/12709403 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/12709403 | http://purl.uniprot.org/core/volume | "17"xsd:string |