| http://purl.uniprot.org/citations/12709443 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12709443 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin-beta receptor (LTbetaR) signaling both play important roles in inflammatory and immune responses through activation of NF-kappaB. Using various deficient mouse embryonic fibroblast cells, we have compared the signaling pathways leading to NF-kappaB induction in response to TNF-alpha and LTbetaR activation. We demonstrate that LTbetaR ligation induces not only RelA/p50 dimers but also RelB/p50 dimers, whereas TNF-alpha induces only RelA/p50 dimers. LTbetaR-induced binding of RelB/p50 requires processing of p100 that is mediated by IKKalpha but is independent of IKKbeta, NEMO/IKKgamma, and RelA. Moreover, we show that RelB, p50, and p100 can associate in the same complex and that TNF-alpha but not LTbeta signaling increases the association of p100 with RelB/p50 dimers in the nucleus, leading to the specific inhibition of RelB DNA binding. These results suggest that the alternative NF-kappaB pathway based on p100 processing may account not only for the activation of RelB/p52 dimers but also for that of RelB/p50 dimers and that p100 regulates the binding activity of RelB/p50 dimers via at least two distinct mechanisms depending on the signaling pathway involved."xsd:string |
| http://purl.uniprot.org/citations/12709443 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m300106200"xsd:string |
| http://purl.uniprot.org/citations/12709443 | http://purl.uniprot.org/core/author | "Baud V."xsd:string |
| http://purl.uniprot.org/citations/12709443 | http://purl.uniprot.org/core/author | "Green D.R."xsd:string |
| http://purl.uniprot.org/citations/12709443 | http://purl.uniprot.org/core/author | "Dejardin E."xsd:string |
| http://purl.uniprot.org/citations/12709443 | http://purl.uniprot.org/core/author | "Korner M."xsd:string |
| http://purl.uniprot.org/citations/12709443 | http://purl.uniprot.org/core/author | "Derudder E."xsd:string |
| http://purl.uniprot.org/citations/12709443 | http://purl.uniprot.org/core/author | "Pritchard L.L."xsd:string |
| http://purl.uniprot.org/citations/12709443 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12709443 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12709443 | http://purl.uniprot.org/core/pages | "23278-23284"xsd:string |
| http://purl.uniprot.org/citations/12709443 | http://purl.uniprot.org/core/title | "RelB/p50 dimers are differentially regulated by tumor necrosis factor-alpha and lymphotoxin-beta receptor activation: critical roles for p100."xsd:string |
| http://purl.uniprot.org/citations/12709443 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12709443 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12709443 |
| http://purl.uniprot.org/citations/12709443 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12709443 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGK6-mappedCitation-12709443 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12709443 |
| http://purl.uniprot.org/uniprot/#_Q0X0E6-mappedCitation-12709443 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12709443 |
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| http://purl.uniprot.org/uniprot/#_A0A0R4J210-mappedCitation-12709443 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12709443 |
| http://purl.uniprot.org/uniprot/#_A0A140LJD6-mappedCitation-12709443 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12709443 |
| http://purl.uniprot.org/uniprot/#_A0A0U5J4W4-mappedCitation-12709443 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12709443 |
| http://purl.uniprot.org/uniprot/#_A0A494B9Y5-mappedCitation-12709443 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12709443 |