| http://purl.uniprot.org/citations/12712206 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12712206 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12712206 | http://www.w3.org/2000/01/rdf-schema#comment | "Inappropriate activation of downstream target genes by the oncoprotein beta-catenin is implicated in development of numerous human cancers. beta-catenin and its fruitfly counterpart Armadillo act as a coactivator in the canonical Wnt/Wingless pathway by binding to Tcf/Lef transcription factors. Here we report a conserved nuclear protein, named Chibby, which was identified in a screen for proteins that directly interact with the C-terminal region of beta-catenin. In mammalian cultured cells we demonstrate that Chibby inhibits beta-catenin-mediated transcriptional activation by competing with Lef-1 to bind to beta-catenin. Inhibition of Drosophila Chibby by RNA interference results in segment polarity defects that mimick a wingless gain-of-function phenotype, and overexpression of the wingless target genes engrailed and Ultrabithorax. In addition, epistasis experiments indicate that chibby acts downstream of wingless and upstream of armadillo."xsd:string |
| http://purl.uniprot.org/citations/12712206 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature01570"xsd:string |
| http://purl.uniprot.org/citations/12712206 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature01570"xsd:string |
| http://purl.uniprot.org/citations/12712206 | http://purl.uniprot.org/core/author | "Lee Y.S."xsd:string |
| http://purl.uniprot.org/citations/12712206 | http://purl.uniprot.org/core/author | "Lee Y.S."xsd:string |
| http://purl.uniprot.org/citations/12712206 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/12712206 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/12712206 | http://purl.uniprot.org/core/author | "Yamaguchi S."xsd:string |
| http://purl.uniprot.org/citations/12712206 | http://purl.uniprot.org/core/author | "Yamaguchi S."xsd:string |
| http://purl.uniprot.org/citations/12712206 | http://purl.uniprot.org/core/author | "Takemaru K."xsd:string |
| http://purl.uniprot.org/citations/12712206 | http://purl.uniprot.org/core/author | "Takemaru K."xsd:string |
| http://purl.uniprot.org/citations/12712206 | http://purl.uniprot.org/core/author | "Moon R.T."xsd:string |
| http://purl.uniprot.org/citations/12712206 | http://purl.uniprot.org/core/author | "Moon R.T."xsd:string |
| http://purl.uniprot.org/citations/12712206 | http://purl.uniprot.org/core/author | "Carthew R.W."xsd:string |
| http://purl.uniprot.org/citations/12712206 | http://purl.uniprot.org/core/author | "Carthew R.W."xsd:string |
| http://purl.uniprot.org/citations/12712206 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12712206 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12712206 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/12712206 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/12712206 | http://purl.uniprot.org/core/pages | "905-909"xsd:string |
| http://purl.uniprot.org/citations/12712206 | http://purl.uniprot.org/core/pages | "905-909"xsd:string |
| http://purl.uniprot.org/citations/12712206 | http://purl.uniprot.org/core/title | "Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway."xsd:string |
| http://purl.uniprot.org/citations/12712206 | http://purl.uniprot.org/core/title | "Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway."xsd:string |