| http://purl.uniprot.org/citations/12715893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12715893 | http://www.w3.org/2000/01/rdf-schema#comment | "Plasminogen activator inhibitor-1 (PAI-1) and two-chain high molecular weight kininogen (HKa) exert anti-adhesive properties in vitronectin-dependent cell adhesion. Here, the hypothesis was tested that these anti-adhesive components promote apoptosis in vascular cells. PAI-1 or HKa induced a 2-to 3-fold increase in apoptosis of human umbilical-vein endothelial cells (HUVEC) and vascular smooth muscle cells (VSMC) adherent to vitronectin, as determined by annexin V-FACS assay, similar to alphav-integrin inhibitor cyclo-(Arg-Gly-Asp-D-Phe-Val)-peptide (cRGDfV). Apoptosis occurred after 12 h incubation and was attributable to caspase 3 activation that in turn induced DNA fragmentation. Induction of apoptosis strongly correlated with the anti-adhesive effect of PAI-1 and HKa on these cells. In contrast, PAI-1 and HKa did not affect fibronectin-dependent adhesion or cell survival. uPA did not influence apoptosis in vitronectin- or fibronectin-adherent cells. In atherosclerotic vessel sections, congruent distribution of vitronectin, PAI-1, HK, and of components of the urokinase plasminogen activator/receptor system with apoptotic cells lining foam cell lesions was demonstrated by immunostaining. These results indicate that inhibition of vitronectin-dependent cell adhesion through PAI-1 and HKa correlates with apoptosis induction in vascular cells mediated through the caspase 3 pathway. Co-distribution of apoptosis with plasminogen activation system components in atherosclerosis exemplifies the significance of anti-adhesive mechanisms and apoptosis for tissue remodeling, such as in neointima development."xsd:string |
| http://purl.uniprot.org/citations/12715893 | http://purl.org/dc/terms/identifier | "doi:10.1515/bc.2003.048"xsd:string |
| http://purl.uniprot.org/citations/12715893 | http://purl.uniprot.org/core/author | "Huang B."xsd:string |
| http://purl.uniprot.org/citations/12715893 | http://purl.uniprot.org/core/author | "Preissner K.T."xsd:string |
| http://purl.uniprot.org/citations/12715893 | http://purl.uniprot.org/core/author | "Chavakis T."xsd:string |
| http://purl.uniprot.org/citations/12715893 | http://purl.uniprot.org/core/author | "Katz N."xsd:string |
| http://purl.uniprot.org/citations/12715893 | http://purl.uniprot.org/core/author | "Bobryshev Y.V."xsd:string |
| http://purl.uniprot.org/citations/12715893 | http://purl.uniprot.org/core/author | "Lord R.S."xsd:string |
| http://purl.uniprot.org/citations/12715893 | http://purl.uniprot.org/core/author | "Al-Fakhri N."xsd:string |
| http://purl.uniprot.org/citations/12715893 | http://purl.uniprot.org/core/author | "Cherian S.M."xsd:string |
| http://purl.uniprot.org/citations/12715893 | http://purl.uniprot.org/core/author | "Schmidt-Woll T."xsd:string |
| http://purl.uniprot.org/citations/12715893 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12715893 | http://purl.uniprot.org/core/name | "Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12715893 | http://purl.uniprot.org/core/pages | "423-435"xsd:string |
| http://purl.uniprot.org/citations/12715893 | http://purl.uniprot.org/core/title | "Induction of apoptosis in vascular cells by plasminogen activator inhibitor-1 and high molecular weight kininogen correlates with their anti-adhesive properties."xsd:string |
| http://purl.uniprot.org/citations/12715893 | http://purl.uniprot.org/core/volume | "384"xsd:string |
| http://purl.uniprot.org/citations/12715893 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12715893 |
| http://purl.uniprot.org/citations/12715893 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12715893 |
| http://purl.uniprot.org/uniprot/P01042#attribution-802E91E16C898441DFB90BE8F9A6F1B9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12715893 |