| http://purl.uniprot.org/citations/12716901 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12716901 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12716901 | http://www.w3.org/2000/01/rdf-schema#comment | "Heterotrimeric protein phosphatase 2A (PP2A) is a major Ser/Thr phosphatase composed of catalytic, structural, and regulatory subunits. Here, we characterize Bbeta2, a novel splice variant of the neuronal Bbeta regulatory subunit with a unique N-terminal tail. Bbeta2 is expressed predominantly in forebrain areas, and PP2A holoenzymes containing Bbeta2 are about 10-fold less abundant than those containing the Bbeta1 (previously Bbeta) isoform. Bbeta2 mRNA is dramatically induced postnatally and in response to neuronal differentiation of a hippocampal progenitor cell line. The divergent N terminus of Bbeta2 does not affect phosphatase activity but encodes a subcellular targeting signal. Bbeta2, but not Bbeta1 or an N-terminal truncation mutant, colocalizes with mitochondria in neuronal PC12 cells. Moreover, the Bbeta2 N-terminal tail is sufficient to target green fluorescent protein to this organelle. Inducible or transient expression of Bbeta2, but neither Bbeta1, Bgamma, nor a Bbeta2 mutant defective in holoenzyme formation, accelerates apoptosis in response to growth factor deprivation. Thus, alternative splicing of a mitochondrial localization signal generates a PP2A holoenzyme involved in neuronal survival signaling."xsd:string |
| http://purl.uniprot.org/citations/12716901 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m302832200"xsd:string |
| http://purl.uniprot.org/citations/12716901 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m302832200"xsd:string |
| http://purl.uniprot.org/citations/12716901 | http://purl.uniprot.org/core/author | "Dagda R.K."xsd:string |
| http://purl.uniprot.org/citations/12716901 | http://purl.uniprot.org/core/author | "Dagda R.K."xsd:string |
| http://purl.uniprot.org/citations/12716901 | http://purl.uniprot.org/core/author | "Strack S."xsd:string |
| http://purl.uniprot.org/citations/12716901 | http://purl.uniprot.org/core/author | "Strack S."xsd:string |
| http://purl.uniprot.org/citations/12716901 | http://purl.uniprot.org/core/author | "Wadzinski B.E."xsd:string |
| http://purl.uniprot.org/citations/12716901 | http://purl.uniprot.org/core/author | "Wadzinski B.E."xsd:string |
| http://purl.uniprot.org/citations/12716901 | http://purl.uniprot.org/core/author | "Zaucha J.A."xsd:string |
| http://purl.uniprot.org/citations/12716901 | http://purl.uniprot.org/core/author | "Zaucha J.A."xsd:string |
| http://purl.uniprot.org/citations/12716901 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12716901 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12716901 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12716901 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12716901 | http://purl.uniprot.org/core/pages | "24976-24985"xsd:string |
| http://purl.uniprot.org/citations/12716901 | http://purl.uniprot.org/core/pages | "24976-24985"xsd:string |
| http://purl.uniprot.org/citations/12716901 | http://purl.uniprot.org/core/title | "A developmentally regulated, neuron-specific splice variant of the variable subunit Bbeta targets protein phosphatase 2A to mitochondria and modulates apoptosis."xsd:string |
| http://purl.uniprot.org/citations/12716901 | http://purl.uniprot.org/core/title | "A developmentally regulated, neuron-specific splice variant of the variable subunit Bbeta targets protein phosphatase 2A to mitochondria and modulates apoptosis."xsd:string |
| http://purl.uniprot.org/citations/12716901 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12716901 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12716901 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12716901 |
| http://purl.uniprot.org/citations/12716901 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12716901 |