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| http://purl.uniprot.org/citations/12716940 | http://www.w3.org/2000/01/rdf-schema#comment | "In the wild-type brain, the Drosophila classic cadherin DE-cadherin is expressed globally by postembryonic neuroblasts and their lineages ("secondary lineages"), as well as glial cells. To address the role of DE-cadherin in the larval brain, we took advantage of the dominant-negative DE-cad(ex) construct, the expression of which was directed to neurons, glial cells, or both. Global expression of DE-cad(ex) driven by a heat pulse during the early second instar resulted in a severe phenotype that included deficits in neural proliferation. Neuroblasts appeared in approximately normal numbers but had highly reduced mitotic activity. When the DE-cad(ex) construct was driven by the glial-specific driver gcm-Gal4, the effect of DE-cad(ex) on neuroblast proliferation could be replicated, which indicates that DE-cadherin acts in glial cells to promote proliferation of neuroblasts. Expression of DE-cad(ex) in neurons, cortex glia, or both results in abnormalities in cortex layering and in trajectories of secondary axons. In the wild-type brain, neuroblasts and neurons generated at different time points are arranged concentrically around the neuropile, with the DE-cadherin-positive neuroblasts and young secondary neurons at the surface, followed by older secondary neurons and primary neurons. Axons of secondary lineages follow a straight radial course toward the neuropile. Processes of glial cells located in the cortex form a scaffold, called trophospongium, that enwraps neuroblasts and neurons. Expression of DE-cad(ex) in neurons, cortex glia, or both disrupted the regular placement of neuroblasts and secondary neurons and resulted in abnormal trajectories of cell body fiber tracts. We conclude that DE-cadherin plays a pivotal role in larval brain proliferation, brain cortex morphogenesis, and axon growth."xsd:string |
| http://purl.uniprot.org/citations/12716940 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.23-08-03325.2003"xsd:string |
| http://purl.uniprot.org/citations/12716940 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/12716940 | http://purl.uniprot.org/core/author | "Dumstrei K."xsd:string |
| http://purl.uniprot.org/citations/12716940 | http://purl.uniprot.org/core/author | "Hartenstein V."xsd:string |
| http://purl.uniprot.org/citations/12716940 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12716940 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/12716940 | http://purl.uniprot.org/core/pages | "3325-3335"xsd:string |
| http://purl.uniprot.org/citations/12716940 | http://purl.uniprot.org/core/title | "Role of DE-cadherin in neuroblast proliferation, neural morphogenesis, and axon tract formation in Drosophila larval brain development."xsd:string |
| http://purl.uniprot.org/citations/12716940 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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