| http://purl.uniprot.org/citations/12718862 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12718862 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12718862 | http://www.w3.org/2000/01/rdf-schema#comment | "Brain dopaminergic transmission is a critical component in numerous vital functions, and its dysfunction is involved in several disorders, including addiction and Parkinson's disease. Responses to dopamine are mediated via G protein-coupled dopamine receptors (D1-D5). Desensitization of G protein-coupled receptors is mediated via phosphorylation by members of the family of G protein-coupled receptor kinases (GRK1-GRK7). Here we show that GRK6-deficient mice are supersensitive to the locomotor-stimulating effect of psychostimulants, including cocaine and amphetamine. In addition, these mice demonstrate an enhanced coupling of striatal D2-like dopamine receptors to G proteins and augmented locomotor response to direct dopamine agonists both in intact and in dopamine-depleted animals. The present study indicates that postsynaptic D2-like dopamine receptors are physiological targets for GRK6 and suggests that this regulatory mechanism contributes to central dopaminergic supersensitivity."xsd:string |
| http://purl.uniprot.org/citations/12718862 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(03)00192-2"xsd:string |
| http://purl.uniprot.org/citations/12718862 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(03)00192-2"xsd:string |
| http://purl.uniprot.org/citations/12718862 | http://purl.uniprot.org/core/author | "Caron M.G."xsd:string |
| http://purl.uniprot.org/citations/12718862 | http://purl.uniprot.org/core/author | "Caron M.G."xsd:string |
| http://purl.uniprot.org/citations/12718862 | http://purl.uniprot.org/core/author | "Lefkowitz R.J."xsd:string |
| http://purl.uniprot.org/citations/12718862 | http://purl.uniprot.org/core/author | "Lefkowitz R.J."xsd:string |
| http://purl.uniprot.org/citations/12718862 | http://purl.uniprot.org/core/author | "Premont R.T."xsd:string |
| http://purl.uniprot.org/citations/12718862 | http://purl.uniprot.org/core/author | "Premont R.T."xsd:string |
| http://purl.uniprot.org/citations/12718862 | http://purl.uniprot.org/core/author | "Gainetdinov R.R."xsd:string |
| http://purl.uniprot.org/citations/12718862 | http://purl.uniprot.org/core/author | "Gainetdinov R.R."xsd:string |
| http://purl.uniprot.org/citations/12718862 | http://purl.uniprot.org/core/author | "Sotnikova T.D."xsd:string |
| http://purl.uniprot.org/citations/12718862 | http://purl.uniprot.org/core/author | "Sotnikova T.D."xsd:string |
| http://purl.uniprot.org/citations/12718862 | http://purl.uniprot.org/core/author | "Cyr M."xsd:string |
| http://purl.uniprot.org/citations/12718862 | http://purl.uniprot.org/core/author | "Cyr M."xsd:string |
| http://purl.uniprot.org/citations/12718862 | http://purl.uniprot.org/core/author | "Kim K.M."xsd:string |
| http://purl.uniprot.org/citations/12718862 | http://purl.uniprot.org/core/author | "Kim K.M."xsd:string |
| http://purl.uniprot.org/citations/12718862 | http://purl.uniprot.org/core/author | "Bohn L.M."xsd:string |
| http://purl.uniprot.org/citations/12718862 | http://purl.uniprot.org/core/author | "Bohn L.M."xsd:string |
| http://purl.uniprot.org/citations/12718862 | http://purl.uniprot.org/core/author | "Laakso A."xsd:string |
| http://purl.uniprot.org/citations/12718862 | http://purl.uniprot.org/core/author | "Laakso A."xsd:string |
| http://purl.uniprot.org/citations/12718862 | http://purl.uniprot.org/core/author | "Macrae A.D."xsd:string |
| http://purl.uniprot.org/citations/12718862 | http://purl.uniprot.org/core/author | "Macrae A.D."xsd:string |