| http://purl.uniprot.org/citations/12719565 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12719565 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12719565 | http://www.w3.org/2000/01/rdf-schema#comment | "To evaluate human immunodeficiency virus type 1 (HIV-1) replication and selection of drug-resistant viruses during seemingly effective highly active antiretroviral therapy (HAART), multiple HIV-1 env and pol sequences were analyzed and viral DNA levels were quantified from nucleoside analog-experienced children prior to and during a median of 5.1 (range, 1.8 to 6.4) years of HAART. Viral replication was detected at different rates, with apparently increasing sensitivity: 1 of 10 by phylogenetic analysis; 2 of 10 by viral evolution with increasing genetic distances from the most recent common ancestor (MRCA) of infection; 3 of 10 by selection of drug-resistant mutants; and 6 of 10 by maintenance of genetic distances from the MRCA. When four- or five-drug antiretroviral regimens were given to these children, persistent plasma viral rebound did not occur despite the accumulation of highly drug-resistant genotypes. Among the four children without genetic evidence of viral replication, a statistically significant decrease in the genetic distance to the MRCA was detected in three, indicating the persistence of a greater number of early compared to recent viruses, and their HIV-1 DNA decreased by > or =0.9 log(10), resulting in lower absolute DNA levels (P = 0.007). This study demonstrates the variable rates of viral replication when HAART has suppressed plasma HIV-1 RNA for years to a median of <50 copies/ml and that combinations of four or five antiretroviral drugs suppress viral replication even after short-term virologic failure of three-drug HAART and despite ongoing accumulation of drug-resistant mutants. Furthermore, the decrease of cellular HIV-1 DNA to low absolute levels in those without genetic evidence of viral replication suggests that monitoring viral DNA during HAART may gauge low-level replication."xsd:string |
| http://purl.uniprot.org/citations/12719565 | http://purl.org/dc/terms/identifier | "doi:10.1128/JVI.77.10.5721-5730.2003"xsd:string |
| http://purl.uniprot.org/citations/12719565 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.77.10.5721-5730.2003"xsd:string |
| http://purl.uniprot.org/citations/12719565 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/12719565 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/12719565 | http://purl.uniprot.org/core/author | "Mullins J.I."xsd:string |
| http://purl.uniprot.org/citations/12719565 | http://purl.uniprot.org/core/author | "Mullins J.I."xsd:string |
| http://purl.uniprot.org/citations/12719565 | http://purl.uniprot.org/core/author | "Learn G.H."xsd:string |
| http://purl.uniprot.org/citations/12719565 | http://purl.uniprot.org/core/author | "Learn G.H."xsd:string |
| http://purl.uniprot.org/citations/12719565 | http://purl.uniprot.org/core/author | "Ellis G.M."xsd:string |
| http://purl.uniprot.org/citations/12719565 | http://purl.uniprot.org/core/author | "Ellis G.M."xsd:string |
| http://purl.uniprot.org/citations/12719565 | http://purl.uniprot.org/core/author | "Mohan K.M."xsd:string |
| http://purl.uniprot.org/citations/12719565 | http://purl.uniprot.org/core/author | "Mohan K.M."xsd:string |
| http://purl.uniprot.org/citations/12719565 | http://purl.uniprot.org/core/author | "Beck I.A."xsd:string |
| http://purl.uniprot.org/citations/12719565 | http://purl.uniprot.org/core/author | "Beck I.A."xsd:string |
| http://purl.uniprot.org/citations/12719565 | http://purl.uniprot.org/core/author | "De Vange S.M."xsd:string |
| http://purl.uniprot.org/citations/12719565 | http://purl.uniprot.org/core/author | "De Vange S.M."xsd:string |
| http://purl.uniprot.org/citations/12719565 | http://purl.uniprot.org/core/author | "Frenkel L.M."xsd:string |
| http://purl.uniprot.org/citations/12719565 | http://purl.uniprot.org/core/author | "Frenkel L.M."xsd:string |
| http://purl.uniprot.org/citations/12719565 | http://purl.uniprot.org/core/author | "Heath L.M."xsd:string |
| http://purl.uniprot.org/citations/12719565 | http://purl.uniprot.org/core/author | "Heath L.M."xsd:string |
| http://purl.uniprot.org/citations/12719565 | http://purl.uniprot.org/core/author | "Holte S.E."xsd:string |
| http://purl.uniprot.org/citations/12719565 | http://purl.uniprot.org/core/author | "Holte S.E."xsd:string |