| http://purl.uniprot.org/citations/12724329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12724329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12724329 | http://www.w3.org/2000/01/rdf-schema#comment | "Human herpesvirus 6 (HHV-6) employs the complement regulator CD46 (membrane cofactor protein) as a receptor for fusion and entry into target cells. Like other known herpesviruses, HHV-6 encodes multiple glycoproteins, several of which have been implicated in the entry process. In this report, we present evidence that glycoprotein H (gH) is the viral component responsible for binding to CD46. Antibodies to CD46 co-immunoprecipitated an approximately 110-kDa protein band specifically associated with HHV-6-infected cells. This protein was identified as gH by selective depletion with an anti-gH monoclonal antibody, as well as by immunoblot analysis with a rabbit hyperimmune serum directed against a gH synthetic peptide. In reciprocal experiments, a monoclonal antibody against HHV-6 gH was found to co-immunoprecipitate CD46. Studies using monoclonal antibodies directed against specific CD46 domains, as well as engineered constructs lacking defined CD46 regions, demonstrated a close correspondence between the CD46 domains involved in the interaction with gH and those previously shown to be critical for HHV-6 fusion (i.e. short consensus repeats 2 and 3)."xsd:string |
| http://purl.uniprot.org/citations/12724329 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m302373200"xsd:string |
| http://purl.uniprot.org/citations/12724329 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m302373200"xsd:string |
| http://purl.uniprot.org/citations/12724329 | http://purl.uniprot.org/core/author | "Lusso P."xsd:string |
| http://purl.uniprot.org/citations/12724329 | http://purl.uniprot.org/core/author | "Lusso P."xsd:string |
| http://purl.uniprot.org/citations/12724329 | http://purl.uniprot.org/core/author | "Greenstone H.L."xsd:string |
| http://purl.uniprot.org/citations/12724329 | http://purl.uniprot.org/core/author | "Greenstone H.L."xsd:string |
| http://purl.uniprot.org/citations/12724329 | http://purl.uniprot.org/core/author | "Berger E.A."xsd:string |
| http://purl.uniprot.org/citations/12724329 | http://purl.uniprot.org/core/author | "Berger E.A."xsd:string |
| http://purl.uniprot.org/citations/12724329 | http://purl.uniprot.org/core/author | "Atkinson J.P."xsd:string |
| http://purl.uniprot.org/citations/12724329 | http://purl.uniprot.org/core/author | "Atkinson J.P."xsd:string |
| http://purl.uniprot.org/citations/12724329 | http://purl.uniprot.org/core/author | "Liszewski M.K."xsd:string |
| http://purl.uniprot.org/citations/12724329 | http://purl.uniprot.org/core/author | "Liszewski M.K."xsd:string |
| http://purl.uniprot.org/citations/12724329 | http://purl.uniprot.org/core/author | "Insinga A."xsd:string |
| http://purl.uniprot.org/citations/12724329 | http://purl.uniprot.org/core/author | "Insinga A."xsd:string |
| http://purl.uniprot.org/citations/12724329 | http://purl.uniprot.org/core/author | "Santoro F."xsd:string |
| http://purl.uniprot.org/citations/12724329 | http://purl.uniprot.org/core/author | "Santoro F."xsd:string |
| http://purl.uniprot.org/citations/12724329 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12724329 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12724329 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12724329 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12724329 | http://purl.uniprot.org/core/pages | "25964-25969"xsd:string |
| http://purl.uniprot.org/citations/12724329 | http://purl.uniprot.org/core/pages | "25964-25969"xsd:string |