| http://purl.uniprot.org/citations/12727921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12727921 | http://www.w3.org/2000/01/rdf-schema#comment | "Stat3 plays an essential role in IL-10 signaling pathways. A myeloid cell-specific deletion of Stat3 resulted in inflammatory cytokine production and development of chronic enterocolitis with enhanced Th1 responses in mice. In this study, we analyzed the mechanism by which a Stat3 deficiency in myeloid cells led to the induction of chronic enterocolitis in vivo. Even in the absence of Stat1, which is essential for IFN-gamma signaling pathways, Stat3 mutant mice developed chronic enterocolitis. TNF-alpha/Stat3 double-mutant mice developed severe chronic enterocolitis with enhanced Th1 cell development. IL-12p40/Stat3 double-mutant mice, however, showed normal Th1 responses and no inflammatory change in the colon. RAG2/Stat3 double-mutant mice did not develop enterocolitis, either. These findings indicate that overproduction of IL-12p40, which induces potent Th1 responses, is essential for the development of chronic enterocolitis in Stat3 mutant mice. Furthermore, enterocolitis was significantly improved and IFN-gamma production by T cells was reduced in TLR4/Stat3 double-mutant mice, indicating that TLR4-mediated recognition of microbial components triggers aberrant IL-12p40 production by myeloid cells, leading to the development of enterocolitis. Thus, this study clearly established a sequential innate and acquired immune mechanism for the development of Th1-dependent enterocolitis."xsd:string |
| http://purl.uniprot.org/citations/12727921 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci17085"xsd:string |
| http://purl.uniprot.org/citations/12727921 | http://purl.uniprot.org/core/author | "Kobayashi M."xsd:string |
| http://purl.uniprot.org/citations/12727921 | http://purl.uniprot.org/core/author | "Takeda K."xsd:string |
| http://purl.uniprot.org/citations/12727921 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/12727921 | http://purl.uniprot.org/core/author | "Kiyono H."xsd:string |
| http://purl.uniprot.org/citations/12727921 | http://purl.uniprot.org/core/author | "Schreiber R.D."xsd:string |
| http://purl.uniprot.org/citations/12727921 | http://purl.uniprot.org/core/author | "Kweon M.N."xsd:string |
| http://purl.uniprot.org/citations/12727921 | http://purl.uniprot.org/core/author | "Kuwata H."xsd:string |
| http://purl.uniprot.org/citations/12727921 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12727921 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/12727921 | http://purl.uniprot.org/core/pages | "1297-1308"xsd:string |
| http://purl.uniprot.org/citations/12727921 | http://purl.uniprot.org/core/title | "Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/12727921 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/12727921 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12727921 |
| http://purl.uniprot.org/citations/12727921 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12727921 |
| http://purl.uniprot.org/uniprot/#_A0A087WSP5-mappedCitation-12727921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12727921 |
| http://purl.uniprot.org/uniprot/#_A0A087WSQ5-mappedCitation-12727921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12727921 |
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| http://purl.uniprot.org/uniprot/#_A0A0U5J4W4-mappedCitation-12727921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12727921 |
| http://purl.uniprot.org/uniprot/#_A2BHU8-mappedCitation-12727921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12727921 |
| http://purl.uniprot.org/uniprot/#_B7ZC18-mappedCitation-12727921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12727921 |