| http://purl.uniprot.org/citations/12727985 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12727985 | http://www.w3.org/2000/01/rdf-schema#comment | "Lipolytic catecholamine resistance in sc fat cells is observed in polycystic ovarian syndrome (PCOS). The mechanisms behind this lipolysis defect were explored in vitro; sc fat cells were obtained from 10 young, nonobese PCOS women and from 14 matched, healthy control women. Fasting plasma glycerol levels were reduced by one third in PCOS (P < 0.05). Adipocytes of PCOS women were about 25% larger than in the controls (P < 0.05) and had 40% reduced noradrenaline-induced lipolysis (P < 0.05), which could be attributed to a 10-fold decreased beta(2)-adrenoceptor sensitivity (P < 0.05) and low ability of cAMP to activate the protein kinase A (PKA)/hormone-sensitive lipase (HSL) complex (P < 0.05). In PCOS, the adipocyte protein content of beta(2)-adrenoceptors, HSL, and the regulatory II beta-component of PKA were 70%, 55%, and 25% decreased, respectively (P < 0.001); but there was no change in the amount of the catalytic subunit of PKA or of beta(1)-adrenoceptors. Thus, lipolytic catecholamine resistance of sc adipocytes in PCOS is probably attributable to a combination of decreased amounts of beta(2)-adrenergic receptors, the regulatory II beta-component of PKA, and HSL. This may cause low in vivo lipolytic activity and enlarged sc fat cell size and promote later development of obesity in PCOS."xsd:string |
| http://purl.uniprot.org/citations/12727985 | http://purl.org/dc/terms/identifier | "doi:10.1210/jc.2002-021573"xsd:string |
| http://purl.uniprot.org/citations/12727985 | http://purl.uniprot.org/core/author | "Ryden M."xsd:string |
| http://purl.uniprot.org/citations/12727985 | http://purl.uniprot.org/core/author | "Arner P."xsd:string |
| http://purl.uniprot.org/citations/12727985 | http://purl.uniprot.org/core/author | "Faulds G."xsd:string |
| http://purl.uniprot.org/citations/12727985 | http://purl.uniprot.org/core/author | "Wahrenberg H."xsd:string |
| http://purl.uniprot.org/citations/12727985 | http://purl.uniprot.org/core/author | "Ek I."xsd:string |
| http://purl.uniprot.org/citations/12727985 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12727985 | http://purl.uniprot.org/core/name | "J Clin Endocrinol Metab"xsd:string |
| http://purl.uniprot.org/citations/12727985 | http://purl.uniprot.org/core/pages | "2269-2273"xsd:string |
| http://purl.uniprot.org/citations/12727985 | http://purl.uniprot.org/core/title | "Mechanisms behind lipolytic catecholamine resistance of subcutaneous fat cells in the polycystic ovarian syndrome."xsd:string |
| http://purl.uniprot.org/citations/12727985 | http://purl.uniprot.org/core/volume | "88"xsd:string |
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