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http://purl.uniprot.org/citations/12730526http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12730526http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To map the locus for susceptibility to psoriasis in patients with psoriatic arthritis.

Methods

Seventy-four patients with psoriatic arthritis and 95 patients with psoriasis vulgaris were included in this study. Polymorphic genes and microsatellite markers centromeric (C1_2_5) and telomeric (C1_4_4, OTF3, HCR and the corneodesmosin gene) to HLA-C were studied in an association analysis. Typing was also performed on a control population of 104 matched donors.

Results

The allele Cw*0602 was associated both with psoriasis [49 vs 21%, Pc<0.0003; odds ratio (OR)=3.6, aetiological factor (AF)=0.72] and with psoriatic arthritis (62 vs 21%, Pc<0.000001; OR=6.1, AF=0.83). In psoriatic patients a susceptibility region telomeric to HLA-C that includes C1_4_4 (56 vs 22%, Pc<0.0002; OR=4.39, AF=0.77), OTF3 (85 vs 60%, Pc<0.0002; OR=3.7, AF=0.73) and HCR (63 vs 26%, Pc<0.00001; OR=3.8, AF=0.74) was observed. In psoriatic arthritis patients the susceptibility region was delimited by HLA-C and C1_4_4 (384 allele, 56 vs 22%, Pc<0.0002; OR=4.37, AF=0.77).

Conclusions

Comparing the susceptibility regions associated with the two diseases, an overlapping interval of 100 kb between HLA-C and OTF3, which might contain the psoriasis gene, can be defined."xsd:string
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http://purl.uniprot.org/citations/12730526http://purl.uniprot.org/core/author"Gonzalez S."xsd:string
http://purl.uniprot.org/citations/12730526http://purl.uniprot.org/core/author"Lopez-Larrea C."xsd:string
http://purl.uniprot.org/citations/12730526http://purl.uniprot.org/core/author"Lopez-Vazquez A."xsd:string
http://purl.uniprot.org/citations/12730526http://purl.uniprot.org/core/author"Martinez-Borra J."xsd:string
http://purl.uniprot.org/citations/12730526http://purl.uniprot.org/core/author"Sanchez del Rio J."xsd:string
http://purl.uniprot.org/citations/12730526http://purl.uniprot.org/core/author"Torre-Alonso J.C."xsd:string
http://purl.uniprot.org/citations/12730526http://purl.uniprot.org/core/author"Santos-Juanes J."xsd:string
http://purl.uniprot.org/citations/12730526http://purl.uniprot.org/core/author"Blanco-Gelaz M.A."xsd:string
http://purl.uniprot.org/citations/12730526http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/12730526http://purl.uniprot.org/core/name"Rheumatology (Oxford)"xsd:string
http://purl.uniprot.org/citations/12730526http://purl.uniprot.org/core/pages"1089-1092"xsd:string
http://purl.uniprot.org/citations/12730526http://purl.uniprot.org/core/title"Psoriasis vulgaris and psoriatic arthritis share a 100 kb susceptibility region telomeric to HLA-C."xsd:string
http://purl.uniprot.org/citations/12730526http://purl.uniprot.org/core/volume"42"xsd:string
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