| http://purl.uniprot.org/citations/12730672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12730672 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatitis C virus (HCV) core protein is a structural viral protein that packages the viral genomic RNA. In addition to this function, HCV core also modulates a number of cellular regulatory functions. In fact, HCV core protein has been found to modulate the expression of the cyclin-dependent inhibitor p21(WAF1/CIP1) and to promote both apoptosis and cell proliferation through its physical interaction with p53. Here, we studied the ability of HCV core to bind the p53-related p73 protein, its isoforms and its deletion mutants. We found that HCV core co-immunoprecipitated with p73 in HepG2 and SAOS-2 cells. Deletion mutational analysis of p73 indicates that the domain involved in HCV core binding is located between amino-acid residues 321-353. We also demonstrate that p73/core interaction results in the nuclear translocation of HCV core protein either in the presence of the p73 alpha or p73 beta tumor-suppressor proteins. In addition, the interaction with HCV core protein prevents p73 alpha, but not p73 beta dependent cell growth arrest in a p53-dependent manner. Our findings demonstrate that HCV core protein may directly influence the various p73 functions, thus playing a role in HCV pathogenesis."xsd:string |
| http://purl.uniprot.org/citations/12730672 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1206333"xsd:string |
| http://purl.uniprot.org/citations/12730672 | http://purl.uniprot.org/core/author | "Cupelli F."xsd:string |
| http://purl.uniprot.org/citations/12730672 | http://purl.uniprot.org/core/author | "Merlo P."xsd:string |
| http://purl.uniprot.org/citations/12730672 | http://purl.uniprot.org/core/author | "Fontemaggi G."xsd:string |
| http://purl.uniprot.org/citations/12730672 | http://purl.uniprot.org/core/author | "Balsano C."xsd:string |
| http://purl.uniprot.org/citations/12730672 | http://purl.uniprot.org/core/author | "Alisi A."xsd:string |
| http://purl.uniprot.org/citations/12730672 | http://purl.uniprot.org/core/author | "Giambartolomei S."xsd:string |
| http://purl.uniprot.org/citations/12730672 | http://purl.uniprot.org/core/author | "Spaziani A."xsd:string |
| http://purl.uniprot.org/citations/12730672 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12730672 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/12730672 | http://purl.uniprot.org/core/pages | "2573-2580"xsd:string |
| http://purl.uniprot.org/citations/12730672 | http://purl.uniprot.org/core/title | "Physical and functional interaction between HCV core protein and the different p73 isoforms."xsd:string |
| http://purl.uniprot.org/citations/12730672 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12730672 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12730672 |
| http://purl.uniprot.org/citations/12730672 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12730672 |
| http://purl.uniprot.org/uniprot/O15350#attribution-057D8AA2DEC33A473BB3122E4DC5BE9B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12730672 |
| http://purl.uniprot.org/uniprot/O15350#attribution-05DB0185A24011115FF3A53EACA7391C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12730672 |
| http://purl.uniprot.org/uniprot/#_P04637-mappedCitation-12730672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12730672 |
| http://purl.uniprot.org/uniprot/P04637 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12730672 |