| http://purl.uniprot.org/citations/12732662 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12732662 | http://www.w3.org/2000/01/rdf-schema#comment | "Mice deficient for the transcriptional coactivator BOB.1/OBF.1 show several defects in B cell differentiation. Numbers of immature transitional B cells in the bone marrow are reduced and fewer B cells reach the periphery. Furthermore, germinal center B cells are absent and marginal zone (MZ) B lymphocytes are markedly reduced. Increased levels of B cell apoptosis in these mice prompted us to analyze expression and function of antiapoptotic proteins. Bcl2 expression is strongly reduced in BOB.1/OBF.1-deficient pre-B cells. When BOB.1/OBF.1-deficient mice were crossed with Bcl2-transgenic mice, B cell development in the bone marrow and numbers of B cells in peripheral lymphoid organs were normalized. However, neither germinal center B cells nor MZ B cells were rescued. Additionally, Bcl2 did not rescue the defects in signaling and affinity maturation found in BOB.1/OBF.1-deficient mice. Interestingly, Bcl2-transgenic mice by themselves show an MZ B cell defect. Virtually no functional MZ B cells were detected in these mice. In contrast, mice deficient for Bcl2 show a relative increase in MZ B cell numbers, indicating a previously undetected function of Bcl2 for this B cell compartment."xsd:string |
| http://purl.uniprot.org/citations/12732662 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20022014"xsd:string |
| http://purl.uniprot.org/citations/12732662 | http://purl.uniprot.org/core/author | "Klein J."xsd:string |
| http://purl.uniprot.org/citations/12732662 | http://purl.uniprot.org/core/author | "Nitschke L."xsd:string |
| http://purl.uniprot.org/citations/12732662 | http://purl.uniprot.org/core/author | "Brunner C."xsd:string |
| http://purl.uniprot.org/citations/12732662 | http://purl.uniprot.org/core/author | "Wirth T."xsd:string |
| http://purl.uniprot.org/citations/12732662 | http://purl.uniprot.org/core/author | "Marinkovic D."xsd:string |
| http://purl.uniprot.org/citations/12732662 | http://purl.uniprot.org/core/author | "Samardzic T."xsd:string |
| http://purl.uniprot.org/citations/12732662 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12732662 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/12732662 | http://purl.uniprot.org/core/pages | "1205-1211"xsd:string |
| http://purl.uniprot.org/citations/12732662 | http://purl.uniprot.org/core/title | "B cell-specific transgenic expression of Bcl2 rescues early B lymphopoiesis but not B cell responses in BOB.1/OBF.1-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/12732662 | http://purl.uniprot.org/core/volume | "197"xsd:string |
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