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http://purl.uniprot.org/citations/12734011http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12734011http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12734011http://www.w3.org/2000/01/rdf-schema#comment"

Background

Innate immunity is the first line of defense against microorganisms in vertebrates and acts by providing an initial barrier to microorganisms and triggering adaptive immune responses. Peptides such as beta-defensins are an important component of this defense, providing a broad spectrum of antimicrobial activity against bacteria, fungi, mycobacteria and several enveloped viruses. Beta-defensins are small cationic peptides that vary in their expression patterns and spectrum of pathogen specificity. Disruptions in beta-defensin function have been implicated in human diseases, including cystic fibrosis, and a fuller understanding of the variety, function and evolution of human beta-defensins might form the basis for novel therapies. Here we use a combination of laboratory and computational techniques to characterize the main human beta-defensin locus on chromosome 8p22-p23.

Results

In addition to known genes in the region we report the genomic structures and expression patterns of four novel human beta-defensin genes and a related pseudogene. These genes show an unusual pattern of evolution, with rapid divergence between second exon sequences that encode the mature beta-defensin peptides matched by relative stasis in first exons that encode signal peptides.

Conclusions

We conclude that the 8p22-p23 locus has evolved by successive rounds of duplication followed by substantial divergence involving positive selection, to produce a diverse cluster of paralogous genes established before the human-baboon divergence more than 23 million years ago. Positive selection, disproportionately favoring alterations in the charge of amino-acid residues, is implicated as driving second exon divergence in these genes."xsd:string
http://purl.uniprot.org/citations/12734011http://purl.org/dc/terms/identifier"doi:10.1186/gb-2003-4-5-r31"xsd:string
http://purl.uniprot.org/citations/12734011http://purl.org/dc/terms/identifier"doi:10.1186/gb-2003-4-5-r31"xsd:string
http://purl.uniprot.org/citations/12734011http://purl.uniprot.org/core/author"Semple C.A."xsd:string
http://purl.uniprot.org/citations/12734011http://purl.uniprot.org/core/author"Dorin J.R."xsd:string
http://purl.uniprot.org/citations/12734011http://purl.uniprot.org/core/author"Dorin J.R."xsd:string
http://purl.uniprot.org/citations/12734011http://purl.uniprot.org/core/author"Rolfe M."xsd:string
http://purl.uniprot.org/citations/12734011http://purl.uniprot.org/core/author"Rolfe M."xsd:string
http://purl.uniprot.org/citations/12734011http://purl.uniprot.org/core/author"Semple C.A.M."xsd:string
http://purl.uniprot.org/citations/12734011http://purl.uniprot.org/core/author"Semple C.A.M."xsd:string
http://purl.uniprot.org/citations/12734011http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/12734011http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/12734011http://purl.uniprot.org/core/name"Genome Biol."xsd:string
http://purl.uniprot.org/citations/12734011http://purl.uniprot.org/core/name"Genome Biol."xsd:string
http://purl.uniprot.org/citations/12734011http://purl.uniprot.org/core/pages"R31.1-R31.11"xsd:string
http://purl.uniprot.org/citations/12734011http://purl.uniprot.org/core/pages"R31.1-R31.11"xsd:string
http://purl.uniprot.org/citations/12734011http://purl.uniprot.org/core/title"Duplication and selection in the evolution of primate beta-defensin genes."xsd:string
http://purl.uniprot.org/citations/12734011http://purl.uniprot.org/core/title"Duplication and selection in the evolution of primate beta-defensin genes."xsd:string
http://purl.uniprot.org/citations/12734011http://purl.uniprot.org/core/volume"4"xsd:string
http://purl.uniprot.org/citations/12734011http://purl.uniprot.org/core/volume"4"xsd:string
http://purl.uniprot.org/citations/12734011http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12734011
http://purl.uniprot.org/citations/12734011http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12734011
http://purl.uniprot.org/citations/12734011http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/12734011
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