| http://purl.uniprot.org/citations/12740575 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12740575 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12740575 | http://www.w3.org/2000/01/rdf-schema#comment | "The immune recognition receptor complex NKG2D-DAP10 on natural killer cells is stimulated by specific ligands carried on virus-infected and malignant cells. Because DAP10 does not have an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic tail, its ability to trigger killing has been debated. Here we show that a crucial Tyr-Ile-Asn-Met amino acid motif in the cytoplasmic tail of DAP10 couples receptor stimulation to the downstream activation of phosphatidylinositol 3-kinase, Vav1, Rho family GTPases and phospholipase C. Unlike that of ITAM-containing receptors, the activation of NKG2D-DAP10 proceeds independently of Syk family protein tyrosine kinases. Yet the signals initiated by NKG2D-DAP10 are fully capable of inducing killing. Our findings identify a previously unknown mechanism by which receptor complexes that lack ITAM motifs can trigger lymphocyte activation."xsd:string |
| http://purl.uniprot.org/citations/12740575 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni929"xsd:string |
| http://purl.uniprot.org/citations/12740575 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni929"xsd:string |
| http://purl.uniprot.org/citations/12740575 | http://purl.uniprot.org/core/author | "Billadeau D.D."xsd:string |
| http://purl.uniprot.org/citations/12740575 | http://purl.uniprot.org/core/author | "Billadeau D.D."xsd:string |
| http://purl.uniprot.org/citations/12740575 | http://purl.uniprot.org/core/author | "Dick C.J."xsd:string |
| http://purl.uniprot.org/citations/12740575 | http://purl.uniprot.org/core/author | "Dick C.J."xsd:string |
| http://purl.uniprot.org/citations/12740575 | http://purl.uniprot.org/core/author | "Schoon R.A."xsd:string |
| http://purl.uniprot.org/citations/12740575 | http://purl.uniprot.org/core/author | "Schoon R.A."xsd:string |
| http://purl.uniprot.org/citations/12740575 | http://purl.uniprot.org/core/author | "Leibson P.J."xsd:string |
| http://purl.uniprot.org/citations/12740575 | http://purl.uniprot.org/core/author | "Leibson P.J."xsd:string |
| http://purl.uniprot.org/citations/12740575 | http://purl.uniprot.org/core/author | "Upshaw J.L."xsd:string |
| http://purl.uniprot.org/citations/12740575 | http://purl.uniprot.org/core/author | "Upshaw J.L."xsd:string |
| http://purl.uniprot.org/citations/12740575 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12740575 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12740575 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/12740575 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/12740575 | http://purl.uniprot.org/core/pages | "557-564"xsd:string |
| http://purl.uniprot.org/citations/12740575 | http://purl.uniprot.org/core/pages | "557-564"xsd:string |
| http://purl.uniprot.org/citations/12740575 | http://purl.uniprot.org/core/title | "NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway."xsd:string |
| http://purl.uniprot.org/citations/12740575 | http://purl.uniprot.org/core/title | "NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway."xsd:string |
| http://purl.uniprot.org/citations/12740575 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/12740575 | http://purl.uniprot.org/core/volume | "4"xsd:string |