| http://purl.uniprot.org/citations/12743034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12743034 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of the extracellular matrix in cutaneous morphogenesis is poorly understood. Here, we describe the essential role of laminin-10 (alpha5beta1gamma1) in hair follicle development. Laminin-10 was present in the basement membrane of elongating hair germs, when other laminins were downregulated, suggesting a role for laminin-10 in hair development. Treatment of human scalp xenografts with antibodies to laminin-10, or its receptor beta1 integrin, produced alopecia. E16.5 Lama5 -/-mouse skin, lacking laminin-10, contained fewer hair germs compared with controls, and after transplantation, Lama5 -/-skin showed a failure of hair germ elongation followed by complete hair follicle regression. Lama5 -/-skin showed defective basement membrane assembly, without measurable increases in anoikis. Instead, Lama5 -/-skin showed decreased expression of early hair markers including sonic hedgehog and Gli1, implicating laminin-10 in developmental signaling. Intriguingly, treatment of Lama5 -/-skin with purified laminin-10 corrected basement membrane defects and restored hair follicle development. We conclude that laminin-10 is required for hair follicle development and report the first use of exogenous protein to correct a cutaneous developmental defect."xsd:string |
| http://purl.uniprot.org/citations/12743034 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdg239"xsd:string |
| http://purl.uniprot.org/citations/12743034 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/12743034 | http://purl.uniprot.org/core/author | "Gao J."xsd:string |
| http://purl.uniprot.org/citations/12743034 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/12743034 | http://purl.uniprot.org/core/author | "Bradley M."xsd:string |
| http://purl.uniprot.org/citations/12743034 | http://purl.uniprot.org/core/author | "Nguyen N.T."xsd:string |
| http://purl.uniprot.org/citations/12743034 | http://purl.uniprot.org/core/author | "Zhang Y.P."xsd:string |
| http://purl.uniprot.org/citations/12743034 | http://purl.uniprot.org/core/author | "Oro A.E."xsd:string |
| http://purl.uniprot.org/citations/12743034 | http://purl.uniprot.org/core/author | "Keene D.R."xsd:string |
| http://purl.uniprot.org/citations/12743034 | http://purl.uniprot.org/core/author | "Miner J.H."xsd:string |
| http://purl.uniprot.org/citations/12743034 | http://purl.uniprot.org/core/author | "Marinkovich M.P."xsd:string |
| http://purl.uniprot.org/citations/12743034 | http://purl.uniprot.org/core/author | "Tzu J."xsd:string |
| http://purl.uniprot.org/citations/12743034 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12743034 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/12743034 | http://purl.uniprot.org/core/pages | "2400-2410"xsd:string |
| http://purl.uniprot.org/citations/12743034 | http://purl.uniprot.org/core/title | "Laminin-10 is crucial for hair morphogenesis."xsd:string |
| http://purl.uniprot.org/citations/12743034 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12743034 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12743034 |
| http://purl.uniprot.org/citations/12743034 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12743034 |
| http://purl.uniprot.org/uniprot/Q61001#attribution-23DAF47CC2734A329B61D076371E0110 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12743034 |
| http://purl.uniprot.org/uniprot/Q61001#attribution-C0651CF6AEAED1AD0B60E21D9A96D85B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12743034 |
| http://purl.uniprot.org/uniprot/P02468#attribution-23DAF47CC2734A329B61D076371E0110 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12743034 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWI2-mappedCitation-12743034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12743034 |