| http://purl.uniprot.org/citations/12743038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12743038 | http://www.w3.org/2000/01/rdf-schema#comment | "Binding of TGFbeta/BMP factors to their receptors leads to translocation of Smad proteins to the nucleus where they activate transcription of target genes. The two-handed zinc finger proteins encoded by Zfhx1a and Zfhx1b, ZEB-1/deltaEF1 and ZEB-2/SIP1, respectively, regulate gene expression and differentiation programs in a number of tissues. Here I demonstrate that ZEB proteins are also crucial regulators of TGFbeta/BMP signaling with opposing effects on this pathway. Both ZEB proteins bind to Smads, but while ZEB-1/deltaEF1 synergizes with Smad proteins to activate transcription, promote osteoblastic differentiation and induce cell growth arrest, the highly related ZEB-2/SIP1 protein has the opposite effect. Finally, the ability of TGFbeta to mediate transcription of TGFbeta-dependent genes and induce growth arrest depends on the presence of endogenous ZEB-1/deltaEF1 protein."xsd:string |
| http://purl.uniprot.org/citations/12743038 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdg225"xsd:string |
| http://purl.uniprot.org/citations/12743038 | http://purl.uniprot.org/core/author | "Postigo A.A."xsd:string |
| http://purl.uniprot.org/citations/12743038 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12743038 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/12743038 | http://purl.uniprot.org/core/pages | "2443-2452"xsd:string |
| http://purl.uniprot.org/citations/12743038 | http://purl.uniprot.org/core/title | "Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/12743038 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12743038 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12743038 |
| http://purl.uniprot.org/citations/12743038 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12743038 |
| http://purl.uniprot.org/uniprot/#_B4DS26-mappedCitation-12743038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12743038 |
| http://purl.uniprot.org/uniprot/#_B2RBI8-mappedCitation-12743038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12743038 |
| http://purl.uniprot.org/uniprot/#_B4DGU2-mappedCitation-12743038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12743038 |
| http://purl.uniprot.org/uniprot/#_B4DSB8-mappedCitation-12743038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12743038 |
| http://purl.uniprot.org/uniprot/#_A0JLS9-mappedCitation-12743038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12743038 |
| http://purl.uniprot.org/uniprot/#_A0JP08-mappedCitation-12743038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12743038 |
| http://purl.uniprot.org/uniprot/#_P37275-mappedCitation-12743038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12743038 |
| http://purl.uniprot.org/uniprot/#_L0R5E9-mappedCitation-12743038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12743038 |
| http://purl.uniprot.org/uniprot/#_Q53TD9-mappedCitation-12743038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12743038 |
| http://purl.uniprot.org/uniprot/#_Q53TG0-mappedCitation-12743038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12743038 |
| http://purl.uniprot.org/uniprot/#_L8EAF3-mappedCitation-12743038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12743038 |
| http://purl.uniprot.org/uniprot/#_O60315-mappedCitation-12743038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12743038 |
| http://purl.uniprot.org/uniprot/#_Q32Q63-mappedCitation-12743038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12743038 |
| http://purl.uniprot.org/uniprot/#_Q60F94-mappedCitation-12743038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12743038 |