| http://purl.uniprot.org/citations/12750383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12750383 | http://www.w3.org/2000/01/rdf-schema#comment | "Werner syndrome (WS) is a premature aging disorder that predisposes affected individuals to cancer development. The affected gene, WRN, encodes an RecQ homologue whose precise biological function remains elusive. Altered DNA recombination is a hallmark of WS cells suggesting that WRN plays an important role in these pathways. Here we report a novel physical and functional interaction between WRN and the homologous recombination mediator protein RAD52. Fluorescence resonance energy transfer (FRET) analyses show that WRN and RAD52 form a complex in vivo that co-localizes in foci associated with arrested replication forks. Biochemical studies demonstrate that RAD52 both inhibits and enhances WRN helicase activity in a DNA structure-dependent manner, whereas WRN increases the efficiency of RAD52-mediated strand annealing between non-duplex DNA and homologous sequences contained within a double-stranded plasmid. These results suggest that coordinated WRN and RAD52 activities are involved in replication fork rescue after DNA damage."xsd:string |
| http://purl.uniprot.org/citations/12750383 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m303885200"xsd:string |
| http://purl.uniprot.org/citations/12750383 | http://purl.uniprot.org/core/author | "Seeberg E."xsd:string |
| http://purl.uniprot.org/citations/12750383 | http://purl.uniprot.org/core/author | "Bjoras M."xsd:string |
| http://purl.uniprot.org/citations/12750383 | http://purl.uniprot.org/core/author | "Otterlei M."xsd:string |
| http://purl.uniprot.org/citations/12750383 | http://purl.uniprot.org/core/author | "von Kobbe C."xsd:string |
| http://purl.uniprot.org/citations/12750383 | http://purl.uniprot.org/core/author | "Bohr V.A."xsd:string |
| http://purl.uniprot.org/citations/12750383 | http://purl.uniprot.org/core/author | "Baynton K."xsd:string |
| http://purl.uniprot.org/citations/12750383 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12750383 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12750383 | http://purl.uniprot.org/core/pages | "36476-36486"xsd:string |
| http://purl.uniprot.org/citations/12750383 | http://purl.uniprot.org/core/title | "WRN interacts physically and functionally with the recombination mediator protein RAD52."xsd:string |
| http://purl.uniprot.org/citations/12750383 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12750383 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12750383 |
| http://purl.uniprot.org/citations/12750383 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12750383 |
| http://purl.uniprot.org/uniprot/P43351#attribution-2E5D01E5EB5484F2D59541CABE0A29EC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12750383 |
| http://purl.uniprot.org/uniprot/#_P54132-mappedCitation-12750383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12750383 |
| http://purl.uniprot.org/uniprot/#_Q14191-mappedCitation-12750383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12750383 |
| http://purl.uniprot.org/uniprot/#_P49959-mappedCitation-12750383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12750383 |
| http://purl.uniprot.org/uniprot/#_Q13472-mappedCitation-12750383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12750383 |
| http://purl.uniprot.org/uniprot/#_Q13535-mappedCitation-12750383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12750383 |
| http://purl.uniprot.org/uniprot/#_O75943-mappedCitation-12750383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12750383 |
| http://purl.uniprot.org/uniprot/#_P38398-mappedCitation-12750383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12750383 |
| http://purl.uniprot.org/uniprot/#_Q06609-mappedCitation-12750383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12750383 |