| http://purl.uniprot.org/citations/12756264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12756264 | http://www.w3.org/2000/01/rdf-schema#comment | "Bronchus-associated lymphoid tissue (BALT) participates in airway immune responses. However, little is known about the lymphocyte-endothelial adhesion cascades that recruit lymphocytes from blood into BALT. We show that high endothelial venules (HEVs) in BALT express substantial levels of VCAM-1, in marked contrast to HEVs in other secondary lymphoid tissues. BALT HEVs also express the L-selectin ligand PNAd. Anti-L-selectin, anti-PNAd, and anti-LFA-1 mAbs almost completely block the homing of B and T lymphocytes into BALT, whereas anti-alpha4 integrin and anti-VCAM-1 mAbs inhibit homing by nearly 40%. alpha4beta7 integrin and MAdCAM-1 are not involved. Importantly, we found that mAbs against alpha4 integrin and VCAM-1 significantly block the migration of total T cells (80% memory phenotype) but not naive T and B cells to BALT. These results suggest that an adhesion cascade, which includes L-selectin/PNAd, alpha4beta1 integrin/VCAM-1, and LFA-1, targets specific lymphocyte subsets to BALT. This high level of involvement of alpha4beta1 integrin/VCAM-1 is unique among secondary lymphoid tissues, and may help unify lymphocyte migration pathways and immune responses in BALT and other bronchopulmonary tissues."xsd:string |
| http://purl.uniprot.org/citations/12756264 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20010685"xsd:string |
| http://purl.uniprot.org/citations/12756264 | http://purl.uniprot.org/core/author | "Xu B."xsd:string |
| http://purl.uniprot.org/citations/12756264 | http://purl.uniprot.org/core/author | "Shan Z."xsd:string |
| http://purl.uniprot.org/citations/12756264 | http://purl.uniprot.org/core/author | "Butcher E.C."xsd:string |
| http://purl.uniprot.org/citations/12756264 | http://purl.uniprot.org/core/author | "Wagner N."xsd:string |
| http://purl.uniprot.org/citations/12756264 | http://purl.uniprot.org/core/author | "Pham L.N."xsd:string |
| http://purl.uniprot.org/citations/12756264 | http://purl.uniprot.org/core/author | "Michie S.A."xsd:string |
| http://purl.uniprot.org/citations/12756264 | http://purl.uniprot.org/core/author | "Magno V."xsd:string |
| http://purl.uniprot.org/citations/12756264 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12756264 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/12756264 | http://purl.uniprot.org/core/pages | "1255-1267"xsd:string |
| http://purl.uniprot.org/citations/12756264 | http://purl.uniprot.org/core/title | "Lymphocyte homing to bronchus-associated lymphoid tissue (BALT) is mediated by L-selectin/PNAd, alpha4beta1 integrin/VCAM-1, and LFA-1 adhesion pathways."xsd:string |
| http://purl.uniprot.org/citations/12756264 | http://purl.uniprot.org/core/volume | "197"xsd:string |
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