| http://purl.uniprot.org/citations/12756271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12756271 | http://www.w3.org/2000/01/rdf-schema#comment | "Leukocyte rolling in postcapillary venules of inflamed tissues is reduced in L-selectin-deficient mice and mice treated with L-selectin blocking antibodies, but the glycoprotein ligand for L-selectin in inflamed venules is unknown. Here, we show that L-selectin-dependent rolling after P-selectin blockade is completely absent in P-selectin glycoprotein ligand-1 (PSGL-1)-/-mice or wild-type mice treated with a PSGL-1 blocking monoclonal antibody. Immunohistochemistry and flow cytometry failed to show PSGL-1 expression on resting or inflamed endothelium or on platelets. To investigate whether leukocyte-expressed PSGL-1 is mediating L-selectin-dependent rolling, we reconstituted lethally irradiated wild-type mice with PSGL-1-/-bone marrow cells. These chimeric mice showed no L-selectin-dependent rolling, suggesting that leukocyte-expressed PSGL-1 mediates L-selectin-dependent rolling. Frame-to-frame video analysis of L-selectin-dependent rolling in wild-type mice showed that the majority of observed L-selectin-dependent leukocyte rolling was between free flowing leukocytes and already adherent leukocytes or possibly leukocyte fragments, followed by E-selectin-dependent leukocyte rolling along the endothelium. Leukocyte rolling was significantly slower for leukocyte-endothelial than leukocyte-leukocyte interactions. We conclude that leukocyte-expressed PSGL-1 serves as the main L-selectin ligand in inflamed postcapillary venules. L-selectin binding to PSGL-1 initiates tethering events that enable L-selectin-independent leukocyte-endothelial interactions. These findings provide a molecular mechanism for the inflammatory defects seen in L-selectin-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/12756271 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20021854"xsd:string |
| http://purl.uniprot.org/citations/12756271 | http://purl.uniprot.org/core/author | "Smith M.L."xsd:string |
| http://purl.uniprot.org/citations/12756271 | http://purl.uniprot.org/core/author | "Xia L."xsd:string |
| http://purl.uniprot.org/citations/12756271 | http://purl.uniprot.org/core/author | "McEver R.P."xsd:string |
| http://purl.uniprot.org/citations/12756271 | http://purl.uniprot.org/core/author | "Ley K."xsd:string |
| http://purl.uniprot.org/citations/12756271 | http://purl.uniprot.org/core/author | "Olson T.S."xsd:string |
| http://purl.uniprot.org/citations/12756271 | http://purl.uniprot.org/core/author | "Sperandio M."xsd:string |
| http://purl.uniprot.org/citations/12756271 | http://purl.uniprot.org/core/author | "Forlow S.B."xsd:string |
| http://purl.uniprot.org/citations/12756271 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12756271 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/12756271 | http://purl.uniprot.org/core/pages | "1355-1363"xsd:string |
| http://purl.uniprot.org/citations/12756271 | http://purl.uniprot.org/core/title | "P-selectin glycoprotein ligand-1 mediates L-selectin-dependent leukocyte rolling in venules."xsd:string |
| http://purl.uniprot.org/citations/12756271 | http://purl.uniprot.org/core/volume | "197"xsd:string |
| http://purl.uniprot.org/citations/12756271 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12756271 |
| http://purl.uniprot.org/citations/12756271 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12756271 |
| http://purl.uniprot.org/uniprot/#_B1B506-mappedCitation-12756271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12756271 |
| http://purl.uniprot.org/uniprot/#_B1B507-mappedCitation-12756271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12756271 |
| http://purl.uniprot.org/uniprot/#_Q62170-mappedCitation-12756271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12756271 |
| http://purl.uniprot.org/uniprot/#_Q3UV83-mappedCitation-12756271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12756271 |
| http://purl.uniprot.org/uniprot/#_Q99L34-mappedCitation-12756271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12756271 |
| http://purl.uniprot.org/uniprot/#_P18337-mappedCitation-12756271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12756271 |
| http://purl.uniprot.org/uniprot/#_Q3TCF3-mappedCitation-12756271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12756271 |
| http://purl.uniprot.org/uniprot/#_Q3TA36-mappedCitation-12756271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12756271 |