| http://purl.uniprot.org/citations/12757707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12757707 | http://www.w3.org/2000/01/rdf-schema#comment | "Spinocerebellar ataxia type 1 (SCA1) is one of several neurological disorders caused by a CAG repeat expansion. In SCA1, this expansion produces an abnormally long polyglutamine tract in the protein ataxin-1. Mutant polyglutamine proteins accumulate in neurons, inducing neurodegeneration, but the mechanism underlying this accumulation has been unclear. We have discovered that the 14-3-3 protein, a multifunctional regulatory molecule, mediates the neurotoxicity of ataxin-1 by binding to and stabilizing ataxin-1, thereby slowing its normal degradation. The association of ataxin-1 with 14-3-3 is regulated by Akt phosphorylation, and in a Drosophila model of SCA1, both 14-3-3 and Akt modulate neurodegeneration. Our finding that phosphatidylinositol 3-kinase/Akt signaling and 14-3-3 cooperate to modulate the neurotoxicity of ataxin-1 provides insight into SCA1 pathogenesis and identifies potential targets for therapeutic intervention."xsd:string |
| http://purl.uniprot.org/citations/12757707 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(03)00349-0"xsd:string |
| http://purl.uniprot.org/citations/12757707 | http://purl.uniprot.org/core/author | "Aitken A."xsd:string |
| http://purl.uniprot.org/citations/12757707 | http://purl.uniprot.org/core/author | "Skoulakis E.M."xsd:string |
| http://purl.uniprot.org/citations/12757707 | http://purl.uniprot.org/core/author | "Orr H.T."xsd:string |
| http://purl.uniprot.org/citations/12757707 | http://purl.uniprot.org/core/author | "Zoghbi H.Y."xsd:string |
| http://purl.uniprot.org/citations/12757707 | http://purl.uniprot.org/core/author | "Botas J."xsd:string |
| http://purl.uniprot.org/citations/12757707 | http://purl.uniprot.org/core/author | "Acevedo S.F."xsd:string |
| http://purl.uniprot.org/citations/12757707 | http://purl.uniprot.org/core/author | "Kaytor M.D."xsd:string |
| http://purl.uniprot.org/citations/12757707 | http://purl.uniprot.org/core/author | "Lam Y.C."xsd:string |
| http://purl.uniprot.org/citations/12757707 | http://purl.uniprot.org/core/author | "Fernandez-Funez P."xsd:string |
| http://purl.uniprot.org/citations/12757707 | http://purl.uniprot.org/core/author | "Chen H.K."xsd:string |
| http://purl.uniprot.org/citations/12757707 | http://purl.uniprot.org/core/author | "Fernandez M.H."xsd:string |
| http://purl.uniprot.org/citations/12757707 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12757707 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/12757707 | http://purl.uniprot.org/core/pages | "457-468"xsd:string |
| http://purl.uniprot.org/citations/12757707 | http://purl.uniprot.org/core/title | "Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1."xsd:string |
| http://purl.uniprot.org/citations/12757707 | http://purl.uniprot.org/core/volume | "113"xsd:string |
| http://purl.uniprot.org/citations/12757707 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12757707 |
| http://purl.uniprot.org/citations/12757707 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12757707 |
| http://purl.uniprot.org/uniprot/#_P54253-mappedCitation-12757707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12757707 |
| http://purl.uniprot.org/uniprot/#_P63104-mappedCitation-12757707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12757707 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEH0-mappedCitation-12757707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12757707 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LIA3-mappedCitation-12757707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12757707 |