| http://purl.uniprot.org/citations/12757932 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12757932 | http://www.w3.org/2000/01/rdf-schema#comment | "Spinocerebellar ataxia type 1 (SCA1) is an autosomal-dominant neurodegenerative disorder characterized by ataxia and progressive motor deterioration. SCA1 is associated with an elongated polyglutamine tract in ataxin-1, the SCA1 gene product. Using the yeast two-hybrid system and co-immunoprecipitation experiments, we have found that p80 coilin, coiled body-specific protein, binds to ataxin-1. In further experiments with deletion mutants, we found that the C-terminal regions of ataxin-1 and p80 coilin were essential for this interaction. In HeLa cells that have been co-transfected with ataxin-1 and p80 coilin, the p80 coilin protein co-localizes with ataxin-1 aggregates in the nucleoplasm. However, immunohistochemical analysis and immunofluorescence assays showed that mutant ataxin-1 aggregates do not redistribute p80 coilin's dot-like structures in the Purkinje cells of SCA1 transgenic mice. This feature of the interaction between ataxin-1 and p80 coilin suggests that p80 coilin might be implicated in altering the function of ataxin-1."xsd:string |
| http://purl.uniprot.org/citations/12757932 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0925-4439(03)00038-3"xsd:string |
| http://purl.uniprot.org/citations/12757932 | http://purl.uniprot.org/core/author | "Hong S."xsd:string |
| http://purl.uniprot.org/citations/12757932 | http://purl.uniprot.org/core/author | "Kang S."xsd:string |
| http://purl.uniprot.org/citations/12757932 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/12757932 | http://purl.uniprot.org/core/author | "Park Y."xsd:string |
| http://purl.uniprot.org/citations/12757932 | http://purl.uniprot.org/core/author | "Ka S."xsd:string |
| http://purl.uniprot.org/citations/12757932 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12757932 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/12757932 | http://purl.uniprot.org/core/pages | "35-42"xsd:string |
| http://purl.uniprot.org/citations/12757932 | http://purl.uniprot.org/core/title | "p80 coilin, a coiled body-specific protein, interacts with ataxin-1, the SCA1 gene product."xsd:string |
| http://purl.uniprot.org/citations/12757932 | http://purl.uniprot.org/core/volume | "1638"xsd:string |
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