| http://purl.uniprot.org/citations/12759260 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12759260 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent studies have shown that caveolin-1 (Cav-1) plays an important role as a regulator of angiogenesis in vitro. Here, we use Cav-1 knockout (KO) mice as a model system to examine the in vivo relevance of these findings. A primary mediator of angiogenesis is basic fibroblast growth factor (bFGF). Thus, we studied bFGF-induced angiogenesis in Cav-1 KO mice using a reconstituted basement membrane system, ie, Matrigel plugs, supplemented with bFGF. In Cav-1 KO mice, implanted Matrigel plugs showed a dramatic reduction in both vessel infiltration and density, as compared with identical plugs implanted in wild-type control mice. We also examined the necessity of Cav-1 to support the angiogenic response of an exogenous tumor by subcutaneously injecting Cav-1 KO mice with the melanoma cell line, B16-F10. We show that tumor weight, volume, and vessel density are all reduced in Cav-1 KO mice, consistent with diminished angiogenesis. Ultrastructural analysis of newly formed capillaries within the exogenous tumors reveals a lack of endothelial caveolae and incomplete capillary formation in Cav-1 KO mice. These results provide novel evidence that Cav-1 and caveolae play an important positive role in the process of pathological angiogenesis in vivo."xsd:string |
| http://purl.uniprot.org/citations/12759260 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0002-9440(10)64337-4"xsd:string |
| http://purl.uniprot.org/citations/12759260 | http://purl.uniprot.org/core/author | "Lee H."xsd:string |
| http://purl.uniprot.org/citations/12759260 | http://purl.uniprot.org/core/author | "Williams T.M."xsd:string |
| http://purl.uniprot.org/citations/12759260 | http://purl.uniprot.org/core/author | "Lisanti M.P."xsd:string |
| http://purl.uniprot.org/citations/12759260 | http://purl.uniprot.org/core/author | "Combs T.P."xsd:string |
| http://purl.uniprot.org/citations/12759260 | http://purl.uniprot.org/core/author | "Ashton A.W."xsd:string |
| http://purl.uniprot.org/citations/12759260 | http://purl.uniprot.org/core/author | "Schubert W."xsd:string |
| http://purl.uniprot.org/citations/12759260 | http://purl.uniprot.org/core/author | "Woodman S.E."xsd:string |
| http://purl.uniprot.org/citations/12759260 | http://purl.uniprot.org/core/author | "Medina F.A."xsd:string |
| http://purl.uniprot.org/citations/12759260 | http://purl.uniprot.org/core/author | "Wyckoff J.B."xsd:string |
| http://purl.uniprot.org/citations/12759260 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12759260 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/12759260 | http://purl.uniprot.org/core/pages | "2059-2068"xsd:string |
| http://purl.uniprot.org/citations/12759260 | http://purl.uniprot.org/core/title | "Caveolin-1 knockout mice show an impaired angiogenic response to exogenous stimuli."xsd:string |
| http://purl.uniprot.org/citations/12759260 | http://purl.uniprot.org/core/volume | "162"xsd:string |
| http://purl.uniprot.org/citations/12759260 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12759260 |
| http://purl.uniprot.org/citations/12759260 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12759260 |
| http://purl.uniprot.org/uniprot/P49817#attribution-6D40A07A952E6C0AA6A80BBD9AEA37B5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12759260 |
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| http://purl.uniprot.org/uniprot/#_D3Z147-mappedCitation-12759260 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12759260 |
| http://purl.uniprot.org/uniprot/#_D3Z148-mappedCitation-12759260 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12759260 |
| http://purl.uniprot.org/uniprot/#_H3BLQ4-mappedCitation-12759260 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12759260 |
| http://purl.uniprot.org/uniprot/#_P15655-mappedCitation-12759260 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12759260 |