| http://purl.uniprot.org/citations/12759416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12759416 | http://www.w3.org/2000/01/rdf-schema#comment | "B6.K(b-)D(b-) mice are devoid of class Ia but express normal levels of class Ib molecules. They have low levels of CD8 T cells in both the thymus as well as peripheral T cell compartments. Although the percentage of splenic CD8 alpha alpha T cells is increased in these animals, approximately 90% of CD8 T cells are CD8 alpha beta. In contrast to B6 animals, most of the CD8 T cells from these mice have a memory phenotype (CD44(high)CD122(high) CD62L(low)) including both CD8 alpha beta and CD8 alpha alpha subsets. In the thymus of B6.K(b-)D(b-) animals, there is a decrease in the percentage of SP CD8 T cells, although most are CD44(low), similar to that seen in B6 mice. The spleens from day 1-old B6 and B6.K(b-)D(b-) mice have a relatively high proportion of CD44(high)CD62L(low) CD8 T cells. However, by day 28 most CD8 T cells in B6 mice have a naive phenotype while in B6.K(b-)D(b-) mice the memory phenotype remains. Unlike CD44(high) cells that are found in B6 animals, most CD44(high) cells from B6.K(b-)D(b-) mice do not secrete IFN-gamma rapidly upon activation. The paucity of CD8 T cells in B6.K(b-)D(b-) mice might be due in part to their inability to undergo homeostatic expansion. Consistent with this, we found that CD8 T cells from these animals expand poorly in X-irradiated syngeneic hosts compared with B6 CD8 T cells that respond to class Ia Ags. We examined homeostatic expansion of B6 CD8 T cells in single as well as double class Ia knockout mice and were able to estimate the fraction of cells reactive against class Ia vs class Ib molecules."xsd:string |
| http://purl.uniprot.org/citations/12759416 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.170.11.5414"xsd:string |
| http://purl.uniprot.org/citations/12759416 | http://purl.uniprot.org/core/author | "Su J."xsd:string |
| http://purl.uniprot.org/citations/12759416 | http://purl.uniprot.org/core/author | "Forman J."xsd:string |
| http://purl.uniprot.org/citations/12759416 | http://purl.uniprot.org/core/author | "Kurepa Z."xsd:string |
| http://purl.uniprot.org/citations/12759416 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12759416 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/12759416 | http://purl.uniprot.org/core/pages | "5414-5420"xsd:string |
| http://purl.uniprot.org/citations/12759416 | http://purl.uniprot.org/core/title | "Memory phenotype of CD8+ T cells in MHC class Ia-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/12759416 | http://purl.uniprot.org/core/volume | "170"xsd:string |
| http://purl.uniprot.org/citations/12759416 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12759416 |
| http://purl.uniprot.org/citations/12759416 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12759416 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1G3-mappedCitation-12759416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12759416 |
| http://purl.uniprot.org/uniprot/#_K7WBQ4-mappedCitation-12759416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12759416 |
| http://purl.uniprot.org/uniprot/#_A0A482CGP7-mappedCitation-12759416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12759416 |
| http://purl.uniprot.org/uniprot/#_A0A482D1Q0-mappedCitation-12759416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12759416 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G2-mappedCitation-12759416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12759416 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G8-mappedCitation-12759416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12759416 |
| http://purl.uniprot.org/uniprot/#_A0A494BA33-mappedCitation-12759416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12759416 |
| http://purl.uniprot.org/uniprot/#_A0A494BAT0-mappedCitation-12759416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12759416 |
| http://purl.uniprot.org/uniprot/#_O19449-mappedCitation-12759416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12759416 |
| http://purl.uniprot.org/uniprot/#_G3UXW2-mappedCitation-12759416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12759416 |
| http://purl.uniprot.org/uniprot/#_G3UZP7-mappedCitation-12759416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12759416 |
| http://purl.uniprot.org/uniprot/#_P04223-mappedCitation-12759416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12759416 |