| http://purl.uniprot.org/citations/12761049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12761049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12761049 | http://www.w3.org/2000/01/rdf-schema#comment | "The hnRNP G family comprises three closely related proteins, hnRNP G, RBMY and hnRNP G-T. We showed previously that they interact with splicing activator proteins, particularly hTra2beta, and suggested that they were involved in regulating Tra2-dependent splicing. We show here that hnRNP G and hTra2beta have opposite effects upon the incorporation of several exons, both being able to act as either an activator or a repressor. HnRNP G acts via a specific sequence to repress the skeletal muscle-specific exon (SK) of human slow skeletal alpha-tropomyosin, TPM3, and stimulates inclusion of the alternative non-muscle exon. The binding of hnRNP G to the exon is antagonized by hTra2beta. The two proteins also have opposite effects upon a dystrophin pseudo-exon. This exon is incorporated in a patient to a higher level in heart muscle than skeletal muscle, causing X-linked dilated cardiomyopathy. It is included to a higher level after transfection of a mini-gene into rodent cardiac myoblasts than into skeletal muscle myoblasts. Co-transfection with hnRNP G represses incorporation in cardiac myoblasts, whereas hTra2beta increases it in skeletal myoblasts. Both the cell specificity and the protein responses depend upon exon sequences. Since the ratio of hnRNP G to Tra2beta mRNA in humans is higher in skeletal muscle than in heart muscle, we propose that the hnRNP G/Tra2beta ratio contributes to the cellular splicing preferences and that the higher proportion of hnRNP G in skeletal muscle plays a role in preventing the incorporation of the pseudo-exon and thus in preventing skeletal muscle dystrophy."xsd:string |
| http://purl.uniprot.org/citations/12761049 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddg136"xsd:string |
| http://purl.uniprot.org/citations/12761049 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddg136"xsd:string |
| http://purl.uniprot.org/citations/12761049 | http://purl.uniprot.org/core/author | "Eperon I.C."xsd:string |
| http://purl.uniprot.org/citations/12761049 | http://purl.uniprot.org/core/author | "Eperon I.C."xsd:string |
| http://purl.uniprot.org/citations/12761049 | http://purl.uniprot.org/core/author | "Chernova T.K."xsd:string |
| http://purl.uniprot.org/citations/12761049 | http://purl.uniprot.org/core/author | "Chernova T.K."xsd:string |
| http://purl.uniprot.org/citations/12761049 | http://purl.uniprot.org/core/author | "Chowdhury H.M."xsd:string |
| http://purl.uniprot.org/citations/12761049 | http://purl.uniprot.org/core/author | "Chowdhury H.M."xsd:string |
| http://purl.uniprot.org/citations/12761049 | http://purl.uniprot.org/core/author | "Nasim M.T."xsd:string |
| http://purl.uniprot.org/citations/12761049 | http://purl.uniprot.org/core/author | "Nasim M.T."xsd:string |
| http://purl.uniprot.org/citations/12761049 | http://purl.uniprot.org/core/author | "Yue B.G."xsd:string |
| http://purl.uniprot.org/citations/12761049 | http://purl.uniprot.org/core/author | "Yue B.G."xsd:string |
| http://purl.uniprot.org/citations/12761049 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12761049 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12761049 | http://purl.uniprot.org/core/name | "Hum. Mol. Genet."xsd:string |
| http://purl.uniprot.org/citations/12761049 | http://purl.uniprot.org/core/name | "Hum. Mol. Genet."xsd:string |
| http://purl.uniprot.org/citations/12761049 | http://purl.uniprot.org/core/pages | "1337-1348"xsd:string |
| http://purl.uniprot.org/citations/12761049 | http://purl.uniprot.org/core/pages | "1337-1348"xsd:string |
| http://purl.uniprot.org/citations/12761049 | http://purl.uniprot.org/core/title | "HnRNP G and Tra2beta: opposite effects on splicing matched by antagonism in RNA binding."xsd:string |
| http://purl.uniprot.org/citations/12761049 | http://purl.uniprot.org/core/title | "HnRNP G and Tra2beta: opposite effects on splicing matched by antagonism in RNA binding."xsd:string |
| http://purl.uniprot.org/citations/12761049 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/12761049 | http://purl.uniprot.org/core/volume | "12"xsd:string |