| http://purl.uniprot.org/citations/12761551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12761551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12761551 | http://www.w3.org/2000/01/rdf-schema#comment | "Acute lymphoblastic leukaemia (ALL) is the commonest form of childhood malignancy, and most cases arise from B-cell clones arrested at the pre-B-cell stage of differentiation. The molecular events that arrest pre-B-cell differentiation in the leukaemic pre-B cells have not been well characterized. Here we show that the differentiation regulator SLP-65 (an adaptor protein also called BLNK or BASH) inhibits pre-B-cell leukaemia in mice. Reconstitution of SLP-65 expression in a SLP-65-/-pre-B-cell line led to enhanced differentiation in vitro and prevented the development of pre-B-cell leukaemia in immune-deficient mice. Tyrosine 96 of SLP-65 was required for this activity. The murine SLP-65-/-pre-B-cell leukaemia resembles human childhood pre-B ALL. Indeed, 16 of the 34 childhood pre-B ALL samples that were tested showed a complete loss or drastic reduction of SLP-65 expression. This loss is probably due to the incorporation of alternative exons into SLP-65 transcripts, leading to premature stop codons. Thus, the somatic loss of SLP-65 and the accompanying block in pre-B-cell differentiation might be one of the primary causes of childhood pre-B ALL."xsd:string |
| http://purl.uniprot.org/citations/12761551 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature01608"xsd:string |
| http://purl.uniprot.org/citations/12761551 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature01608"xsd:string |
| http://purl.uniprot.org/citations/12761551 | http://purl.uniprot.org/core/author | "Niemeyer C.M."xsd:string |
| http://purl.uniprot.org/citations/12761551 | http://purl.uniprot.org/core/author | "Niemeyer C.M."xsd:string |
| http://purl.uniprot.org/citations/12761551 | http://purl.uniprot.org/core/author | "Pelkonen J."xsd:string |
| http://purl.uniprot.org/citations/12761551 | http://purl.uniprot.org/core/author | "Pelkonen J."xsd:string |
| http://purl.uniprot.org/citations/12761551 | http://purl.uniprot.org/core/author | "Schrappe M."xsd:string |
| http://purl.uniprot.org/citations/12761551 | http://purl.uniprot.org/core/author | "Schrappe M."xsd:string |
| http://purl.uniprot.org/citations/12761551 | http://purl.uniprot.org/core/author | "Reth M."xsd:string |
| http://purl.uniprot.org/citations/12761551 | http://purl.uniprot.org/core/author | "Reth M."xsd:string |
| http://purl.uniprot.org/citations/12761551 | http://purl.uniprot.org/core/author | "Bossaller L."xsd:string |
| http://purl.uniprot.org/citations/12761551 | http://purl.uniprot.org/core/author | "Bossaller L."xsd:string |
| http://purl.uniprot.org/citations/12761551 | http://purl.uniprot.org/core/author | "Flemming A."xsd:string |
| http://purl.uniprot.org/citations/12761551 | http://purl.uniprot.org/core/author | "Flemming A."xsd:string |
| http://purl.uniprot.org/citations/12761551 | http://purl.uniprot.org/core/author | "Jumaa H."xsd:string |
| http://purl.uniprot.org/citations/12761551 | http://purl.uniprot.org/core/author | "Jumaa H."xsd:string |
| http://purl.uniprot.org/citations/12761551 | http://purl.uniprot.org/core/author | "Lotz M."xsd:string |
| http://purl.uniprot.org/citations/12761551 | http://purl.uniprot.org/core/author | "Lotz M."xsd:string |
| http://purl.uniprot.org/citations/12761551 | http://purl.uniprot.org/core/author | "Portugal K."xsd:string |
| http://purl.uniprot.org/citations/12761551 | http://purl.uniprot.org/core/author | "Portugal K."xsd:string |
| http://purl.uniprot.org/citations/12761551 | http://purl.uniprot.org/core/author | "Postila V."xsd:string |
| http://purl.uniprot.org/citations/12761551 | http://purl.uniprot.org/core/author | "Postila V."xsd:string |