| http://purl.uniprot.org/citations/12765483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12765483 | http://www.w3.org/2000/01/rdf-schema#comment | "Background and aimsGenetic susceptibility to primary sclerosing cholangitis is associated with several different HLA haplotypes, though a single "shared" susceptibility allele has yet to be identified. Most recently, attention has focussed on the MICA alleles in close proximity to the HLA class I, B locus. However, although there are strong associations with MICA*008, implicating this or a closely linked allele as major risk factors, this explanation alone does not account for all of the MHC-encoded susceptibility and resistance to PSC. The present study re-examines HLA class II associations in a large single centre series of well-characterised PSC patients. The specific aims of the study were to test existing associations and to develop hypotheses which together may account for all, or the majority, of the MHC-encoded susceptibility in PSC.MethodsA total of 148 adult white northern European patients and 134 control subjects were studied. HLA DRB1, DQA1, DQB1 alleles and DRB1*04, DRB1*13 and DRB3 subtypes were determined by standard PCR-genotyping.ResultsThe primary associations with the DRB3*0101--DRB1*0301--DQA1*0501--DQB1*0201 and DRB1*1301--DQA1*0103--DQB1*0603 haplotypes were confirmed (O.R. = 2.69, p < 0.0000025 and O.R. = 3.8, p < 0.0005). In addition the strong protective influence of the DRB1*04--DQB1*0302 haplotype was reaffirmed (O.R. = 0.26, p < 0.000025) and a previously unreported negative (i.e. protective) association with the DRB1*0701--DQB1*0303 haplotype was also demonstrated (O.R. = 0.15, p < 0.005). Further analysis suggested that susceptibility/resistance encoded by the second and third susceptibility haplotypes and by the two resistance haplotypes may be determined by specific amino acids at DQbeta-87 and DQbeta-55, respectively."xsd:string |
| http://purl.uniprot.org/citations/12765483 | http://purl.org/dc/terms/identifier | "doi:10.1080/0891693021000054093"xsd:string |
| http://purl.uniprot.org/citations/12765483 | http://purl.uniprot.org/core/author | "Donaldson P.T."xsd:string |
| http://purl.uniprot.org/citations/12765483 | http://purl.uniprot.org/core/author | "Norris S."xsd:string |
| http://purl.uniprot.org/citations/12765483 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12765483 | http://purl.uniprot.org/core/name | "Autoimmunity"xsd:string |
| http://purl.uniprot.org/citations/12765483 | http://purl.uniprot.org/core/pages | "555-564"xsd:string |
| http://purl.uniprot.org/citations/12765483 | http://purl.uniprot.org/core/title | "Evaluation of the role of MHC class II alleles, haplotypes and selected amino acid sequences in primary sclerosing cholangitis."xsd:string |
| http://purl.uniprot.org/citations/12765483 | http://purl.uniprot.org/core/volume | "35"xsd:string |
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