| http://purl.uniprot.org/citations/12766170 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12766170 | http://www.w3.org/2000/01/rdf-schema#comment | "The Gab1 docking protein forms a platform for the assembly of a multiprotein signaling complex downstream from receptor tyrosine kinases. In general, recruitment of Gab1 occurs indirectly, via the adapter protein Grb2. In addition, Gab1 interacts with the Met/hepatocyte growth factor receptor in a Grb2-independent manner. This interaction requires a Met binding domain (MBD) in Gab1 and is essential for Met-mediated epithelial morphogenesis. The Gab1 MBD has been proposed to act as a phosphotyrosine binding domain that binds Tyr-1349 in the Met receptor. We show that a 16-amino acid motif within the Gab1 MBD is sufficient for interaction with the Met receptor, suggesting that it is unlikely that the Gab1 MBD forms a structured domain. Alternatively, the structural integrity of the Met receptor, and residues upstream of Tyr-1349 located in the C-terminal lobe of the kinase domain, are required for Grb2-independent interaction with the Gab1 MBD. Moreover, the substitution of Tyr-1349 with an acidic residue allows for the recruitment of the Gab1 MBD and for phosphorylation of Gab1. We propose that Gab1 and the Met receptor interact in a novel manner, such that the activated kinase domain of Met and the negative charge of phosphotyrosine 1349 engage the Gab1 MBD as an extended peptide ligand."xsd:string |
| http://purl.uniprot.org/citations/12766170 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m302675200"xsd:string |
| http://purl.uniprot.org/citations/12766170 | http://purl.uniprot.org/core/author | "Park M."xsd:string |
| http://purl.uniprot.org/citations/12766170 | http://purl.uniprot.org/core/author | "Saucier C."xsd:string |
| http://purl.uniprot.org/citations/12766170 | http://purl.uniprot.org/core/author | "Lock L.S."xsd:string |
| http://purl.uniprot.org/citations/12766170 | http://purl.uniprot.org/core/author | "Frigault M.M."xsd:string |
| http://purl.uniprot.org/citations/12766170 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12766170 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12766170 | http://purl.uniprot.org/core/pages | "30083-30090"xsd:string |
| http://purl.uniprot.org/citations/12766170 | http://purl.uniprot.org/core/title | "Grb2-independent recruitment of Gab1 requires the C-terminal lobe and structural integrity of the Met receptor kinase domain."xsd:string |
| http://purl.uniprot.org/citations/12766170 | http://purl.uniprot.org/core/volume | "278"xsd:string |
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