| http://purl.uniprot.org/citations/12767919 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12767919 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12767919 | http://www.w3.org/2000/01/rdf-schema#comment | "Refsum disease (RfD) is an autosomal recessive neurologic disorder of the lipid metabolism. We have identified a novel murine long-chain acyl-CoA synthetase (mLACS) associated with the RfD gene using yeast two-hybrid assay. Northern blot analyses revealed that mLACS was expressed mainly in the brain and testis. mLACS was highly expressed in the brain at 2 weeks after birth and maintained through adult life. Expressions of the brain-specific LACS family increased in the PC12 cells undergoing neurite outgrowth by nerve growth factor. mLACS preferentially catalyzed the formation of arachidonoyl-CoA more than palmitoyl-CoA or oleoyl-CoA in PC12 cells. Triacsin C, an inhibitor of LACS, suppressed the cell proliferation and decreased mLACS expression in parent PC12 cells, but not in stably anti-sense mLACS cDNA-transfected cells. Our results indicate that mLACS participates in neuronal cell proliferation and differentiation, and interaction of the RfD gene with brain-selective mLACS may be involved in the pathogenesis of RfD."xsd:string |
| http://purl.uniprot.org/citations/12767919 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(03)00859-3"xsd:string |
| http://purl.uniprot.org/citations/12767919 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(03)00859-3"xsd:string |
| http://purl.uniprot.org/citations/12767919 | http://purl.uniprot.org/core/author | "Kim K.K."xsd:string |
| http://purl.uniprot.org/citations/12767919 | http://purl.uniprot.org/core/author | "Kim K.K."xsd:string |
| http://purl.uniprot.org/citations/12767919 | http://purl.uniprot.org/core/author | "Baik Y.H."xsd:string |
| http://purl.uniprot.org/citations/12767919 | http://purl.uniprot.org/core/author | "Baik Y.H."xsd:string |
| http://purl.uniprot.org/citations/12767919 | http://purl.uniprot.org/core/author | "Kee H.J."xsd:string |
| http://purl.uniprot.org/citations/12767919 | http://purl.uniprot.org/core/author | "Kee H.J."xsd:string |
| http://purl.uniprot.org/citations/12767919 | http://purl.uniprot.org/core/author | "Koh J.T."xsd:string |
| http://purl.uniprot.org/citations/12767919 | http://purl.uniprot.org/core/author | "Koh J.T."xsd:string |
| http://purl.uniprot.org/citations/12767919 | http://purl.uniprot.org/core/author | "Lee Z.H."xsd:string |
| http://purl.uniprot.org/citations/12767919 | http://purl.uniprot.org/core/author | "Lee Z.H."xsd:string |
| http://purl.uniprot.org/citations/12767919 | http://purl.uniprot.org/core/author | "Yang S.Y."xsd:string |
| http://purl.uniprot.org/citations/12767919 | http://purl.uniprot.org/core/author | "Yang S.Y."xsd:string |
| http://purl.uniprot.org/citations/12767919 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12767919 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12767919 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/12767919 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/12767919 | http://purl.uniprot.org/core/pages | "925-933"xsd:string |
| http://purl.uniprot.org/citations/12767919 | http://purl.uniprot.org/core/pages | "925-933"xsd:string |
| http://purl.uniprot.org/citations/12767919 | http://purl.uniprot.org/core/title | "A novel murine long-chain acyl-CoA synthetase expressed in brain participates in neuronal cell proliferation."xsd:string |
| http://purl.uniprot.org/citations/12767919 | http://purl.uniprot.org/core/title | "A novel murine long-chain acyl-CoA synthetase expressed in brain participates in neuronal cell proliferation."xsd:string |