| http://purl.uniprot.org/citations/12768083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12768083 | http://www.w3.org/2000/01/rdf-schema#comment | "Simplex and multiplex families with IgA nephropathy (IgAN) have been reported from several ethnic backgrounds, providing the strongest evidence of a role for genetic factors in pathogenesis of IgAN. From a phenotypic point of view, familial and sporadic IgAN cannot be differentiated, and the main clinical and histological features are similar. Traditionally, the case-control study design was employed to identify associations between particular candidate genes, for example, HLA antigens the uteroglobin gene and IgAN, giving conflicting results. Recently, a different approach, using linkage analysis, was undertaken by geneticists at Yale University. A 10-cM genome-wide screen was performed in 30 multiplex IgAN pedigrees, and one locus was mapped (IGAN-1) on chromosome 6q22-23. Future study will be focused on the identification of the gene underlying IGAN-1. This will enable us to understand the molecular pathogenetic basis of IgAN."xsd:string |
| http://purl.uniprot.org/citations/12768083 | http://purl.uniprot.org/core/author | "Scolari F."xsd:string |
| http://purl.uniprot.org/citations/12768083 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12768083 | http://purl.uniprot.org/core/name | "J Nephrol"xsd:string |
| http://purl.uniprot.org/citations/12768083 | http://purl.uniprot.org/core/pages | "317-320"xsd:string |
| http://purl.uniprot.org/citations/12768083 | http://purl.uniprot.org/core/title | "Inherited forms of IgA nephropathy."xsd:string |
| http://purl.uniprot.org/citations/12768083 | http://purl.uniprot.org/core/volume | "16"xsd:string |
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