| http://purl.uniprot.org/citations/12769844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12769844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12769844 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcription regulatory oncoprotein c-Myc controls genes involved in cell growth, apoptosis, and oncogenesis. c-Myc is turned over very quickly through the ubiquitin/proteasome pathway. The proteins involved in this process are still unknown. We have found that Skp2 interacts with c-Myc and participates in its ubiquitylation and degradation. The interaction between Skp2 and c-Myc occurs during the G1 to S phase transition of the cell cycle in normal lymphocytes. Surprisingly, Skp2 enhances c-Myc-induced S phase transition and activates c-Myc target genes in a Myc-dependent manner. Further, Myc-induced transcription was shown to be Skp2 dependent, suggesting interdependence between c-Myc and Skp2 in activation of transcription. Moreover, Myc-dependent association of Skp2, ubiquitylated proteins, and subunits of the proteasome to a c-Myc target promoter was demonstrated in vivo. The results suggest that Skp2 is a transcriptional cofactor for c-Myc and indicates a close relationship between transcription activation and transcription factor ubiquitination."xsd:string |
| http://purl.uniprot.org/citations/12769844 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(03)00193-x"xsd:string |
| http://purl.uniprot.org/citations/12769844 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(03)00193-x"xsd:string |
| http://purl.uniprot.org/citations/12769844 | http://purl.uniprot.org/core/author | "Nakayama K."xsd:string |
| http://purl.uniprot.org/citations/12769844 | http://purl.uniprot.org/core/author | "Nakayama K."xsd:string |
| http://purl.uniprot.org/citations/12769844 | http://purl.uniprot.org/core/author | "Wu S."xsd:string |
| http://purl.uniprot.org/citations/12769844 | http://purl.uniprot.org/core/author | "Wu S."xsd:string |
| http://purl.uniprot.org/citations/12769844 | http://purl.uniprot.org/core/author | "Johansson S."xsd:string |
| http://purl.uniprot.org/citations/12769844 | http://purl.uniprot.org/core/author | "Johansson S."xsd:string |
| http://purl.uniprot.org/citations/12769844 | http://purl.uniprot.org/core/author | "Nakayama K.I."xsd:string |
| http://purl.uniprot.org/citations/12769844 | http://purl.uniprot.org/core/author | "Nakayama K.I."xsd:string |
| http://purl.uniprot.org/citations/12769844 | http://purl.uniprot.org/core/author | "Kerppola T.K."xsd:string |
| http://purl.uniprot.org/citations/12769844 | http://purl.uniprot.org/core/author | "Kerppola T.K."xsd:string |
| http://purl.uniprot.org/citations/12769844 | http://purl.uniprot.org/core/author | "Castell A."xsd:string |
| http://purl.uniprot.org/citations/12769844 | http://purl.uniprot.org/core/author | "Castell A."xsd:string |
| http://purl.uniprot.org/citations/12769844 | http://purl.uniprot.org/core/author | "Bahram F."xsd:string |
| http://purl.uniprot.org/citations/12769844 | http://purl.uniprot.org/core/author | "Bahram F."xsd:string |
| http://purl.uniprot.org/citations/12769844 | http://purl.uniprot.org/core/author | "Hydbring P."xsd:string |
| http://purl.uniprot.org/citations/12769844 | http://purl.uniprot.org/core/author | "Hydbring P."xsd:string |
| http://purl.uniprot.org/citations/12769844 | http://purl.uniprot.org/core/author | "von der Lehr N."xsd:string |
| http://purl.uniprot.org/citations/12769844 | http://purl.uniprot.org/core/author | "von der Lehr N."xsd:string |
| http://purl.uniprot.org/citations/12769844 | http://purl.uniprot.org/core/author | "Cetinkaya C."xsd:string |
| http://purl.uniprot.org/citations/12769844 | http://purl.uniprot.org/core/author | "Cetinkaya C."xsd:string |