| http://purl.uniprot.org/citations/12770952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12770952 | http://www.w3.org/2000/01/rdf-schema#comment | "1 Urotensin-II (U-II) is among the most potent mammalian vasoconstrictors identified and may play a role in the aetiology of essential hypertension. Currently, only one mouse U-II receptor (UT) gene has been cloned. It is postulated that this protein is solely responsible for mediating U-II-induced vasoconstriction. 2 This hypothesis has been investigated in the present study, which assessed basal haemodynamics and vascular reactivity to hU-II in wild-type (UT((+/+))) and UT receptor knockout (UT((-/-))) mice. 3 Basal left ventricular end-diastolic and end-systolic volumes/pressures, stroke volumes, mean arterial blood pressures, heart rates, cardiac outputs and ejection fractions in UT((+/+)) mice and in UT((-/-)) mice were similar. 4 Relative to UT((+/+)) mouse isolated thoracic aorta, where hU-II was a potent spasmogen (pEC(50)=8.26+/-0.08) that evoked relatively little vasoconstriction (17+/-2% 60 mM KCl), vessels isolated from UT((-/-)) mice did not respond to hU-II. However, in contrast, the superior mesenteric artery isolated from both the genotypes did not contract in the presence of hU-II. Reactivity to unrelated vasoconstrictors (phenylephrine, endothelin-1, KCl) and endothelium-dependent/independent vasodilator agents (carbachol, sodium nitroprusside) was similar in the aorta and superior mesenteric arteries isolated from both the genotypes. 5 The present study is the first to directly link hU-II-induced vasoconstriction with the UT receptor. Deletion of the UT receptor gene results in loss of hU-II contractile action with no 'nonspecific' alterations in vascular reactivity. However, as might be predicted based on the limited contractile efficacy recorded in vitro, the contribution that hU-II and its receptor make to basal systemic haemodynamics appears to be negligible in this species."xsd:string |
| http://purl.uniprot.org/citations/12770952 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.bjp.0705254"xsd:string |
| http://purl.uniprot.org/citations/12770952 | http://purl.uniprot.org/core/author | "Ao Z."xsd:string |
| http://purl.uniprot.org/citations/12770952 | http://purl.uniprot.org/core/author | "Willette R.N."xsd:string |
| http://purl.uniprot.org/citations/12770952 | http://purl.uniprot.org/core/author | "Douglas S.A."xsd:string |
| http://purl.uniprot.org/citations/12770952 | http://purl.uniprot.org/core/author | "Harrison S.M."xsd:string |
| http://purl.uniprot.org/citations/12770952 | http://purl.uniprot.org/core/author | "Johns D.G."xsd:string |
| http://purl.uniprot.org/citations/12770952 | http://purl.uniprot.org/core/author | "Coatney R.W."xsd:string |
| http://purl.uniprot.org/citations/12770952 | http://purl.uniprot.org/core/author | "Behm D.J."xsd:string |
| http://purl.uniprot.org/citations/12770952 | http://purl.uniprot.org/core/author | "Doe C.P."xsd:string |
| http://purl.uniprot.org/citations/12770952 | http://purl.uniprot.org/core/author | "Grau E.V."xsd:string |
| http://purl.uniprot.org/citations/12770952 | http://purl.uniprot.org/core/author | "Maniscalco K."xsd:string |
| http://purl.uniprot.org/citations/12770952 | http://purl.uniprot.org/core/author | "Pickering S.J."xsd:string |
| http://purl.uniprot.org/citations/12770952 | http://purl.uniprot.org/core/author | "Woods T.N."xsd:string |
| http://purl.uniprot.org/citations/12770952 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12770952 | http://purl.uniprot.org/core/name | "Br J Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/12770952 | http://purl.uniprot.org/core/pages | "464-472"xsd:string |
| http://purl.uniprot.org/citations/12770952 | http://purl.uniprot.org/core/title | "Deletion of the UT receptor gene results in the selective loss of urotensin-II contractile activity in aortae isolated from UT receptor knockout mice."xsd:string |
| http://purl.uniprot.org/citations/12770952 | http://purl.uniprot.org/core/volume | "139"xsd:string |
| http://purl.uniprot.org/citations/12770952 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12770952 |
| http://purl.uniprot.org/citations/12770952 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12770952 |
| http://purl.uniprot.org/uniprot/#_Q05AD1-mappedCitation-12770952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12770952 |
| http://purl.uniprot.org/uniprot/#_Q8VIH9-mappedCitation-12770952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12770952 |
| http://purl.uniprot.org/uniprot/Q05AD1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12770952 |