| http://purl.uniprot.org/citations/12771217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12771217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12771217 | http://www.w3.org/2000/01/rdf-schema#comment | "Vimentin, a member of the intermediate filament protein family, is regulated both developmentally and tissue specifically. It is also a marker of the metastatic potential of many tumor cells. Pre viously, the human vimentin promoter has been shown to contain multiple elements for the binding of both positive- and negative-acting regulatory factors. Transient transfection analysis of various vimentin 5'-end promoter sequences and mutants thereof fused to a reporter gene further defined two regulatory elements, a positive element that binds Sp1 and a negative element that binds the protein ZBP-89. ZBP-89 has been shown to be either a repressor or an activator of gene expression, depending on the promoter. Here, we show that for vimentin, both ZBP-89 and ZBP-99 repress reporter gene expression in Schneider (S2) cells. Deletion constructs confirm that the glutamine-rich region of Sp1 is required to enhance vimentin transcription, whereas the N-terminus of ZBP-89 is required to interact with Sp1 and repress gene expression. The overexpression of hTAF(II)130 can alleviate ZBP-89 repression in S2 cells, suggesting how ZBP-89 might serve to block gene expression."xsd:string |
| http://purl.uniprot.org/citations/12771217 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkg380"xsd:string |
| http://purl.uniprot.org/citations/12771217 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkg380"xsd:string |
| http://purl.uniprot.org/citations/12771217 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/12771217 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/12771217 | http://purl.uniprot.org/core/author | "Zehner Z.E."xsd:string |
| http://purl.uniprot.org/citations/12771217 | http://purl.uniprot.org/core/author | "Zehner Z.E."xsd:string |
| http://purl.uniprot.org/citations/12771217 | http://purl.uniprot.org/core/author | "Diab I.H."xsd:string |
| http://purl.uniprot.org/citations/12771217 | http://purl.uniprot.org/core/author | "Diab I.H."xsd:string |
| http://purl.uniprot.org/citations/12771217 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12771217 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12771217 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |
| http://purl.uniprot.org/citations/12771217 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |
| http://purl.uniprot.org/citations/12771217 | http://purl.uniprot.org/core/pages | "2900-2914"xsd:string |
| http://purl.uniprot.org/citations/12771217 | http://purl.uniprot.org/core/pages | "2900-2914"xsd:string |
| http://purl.uniprot.org/citations/12771217 | http://purl.uniprot.org/core/title | "ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator, Sp1."xsd:string |
| http://purl.uniprot.org/citations/12771217 | http://purl.uniprot.org/core/title | "ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator, Sp1."xsd:string |
| http://purl.uniprot.org/citations/12771217 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/12771217 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/12771217 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12771217 |
| http://purl.uniprot.org/citations/12771217 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12771217 |
| http://purl.uniprot.org/citations/12771217 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12771217 |
| http://purl.uniprot.org/citations/12771217 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12771217 |